In this podcast, I’m going solo to talk about ketogenic dieting because it’s getting more and more hype these days for losing fat, gaining muscle, and improving general health and well-being.
The question, of course, is whether or not it can live up to its reputation, and as you’ll see, my current answer is no, it can’t. I’ve done quite a bit of research on it, and my take is that keto dieting makes sense for certain people under certain conditions, but these people are in the minority, and you’re probably not one of them.
Here are a few of the things you’re going to learn in this episode…
- Why what commonly passes for “ketogenic dieting” in the fitness space isn’t true ketogenic dieting.
- Why the ketogenic diet can help you lose weight faster — in the short term at least — but probably can’t help you lose fat faster.
- Why the ketogenic diet isn’t optimal for gaining muscle and strength, and why a high-protein & high-carb diet is better.
- How the ketogenic diet can benefit your overall health and well-being.
- How to know whether the ketogenic diet is right for you or not.
- And more…
Enjoy!
TIMESTAMPS:
3:17 – Why does fasting suppress epileptic seizures?
4:09 – What is the purpose of the ketogenic diet?
5:21 – How does the ketogenic diet work?
6:33 – Does keto help you lose weight faster than traditional dieting?
14:05 – Does keto help muscle building?
21:35 – What about studies showing that low-carb is better for gaining muscle and strength?
25:50 – Does keto dieting have health benefits?
What did you think of this episode? Have anything else to share? Let me know in the comments below!
Scientific References +
- Bough, K. J., & Rho, J. M. (2007). Anticonvulsant mechanisms of the ketogenic diet. In Epilepsia (Vol. 48, Issue 1, pp. 43–58). Epilepsia. https://doi.org/10.1111/j.1528-1167.2007.00915.x
- Stafstrom, C. E., & Rho, J. M. (2012). The ketogenic diet as a treatment paradigm for diverse neurological disorders. Frontiers in Pharmacology, 3 APR. https://doi.org/10.3389/fphar.2012.00059
- Smith, R. N., Mann, N. J., Braue, A., Mäkeläinen, H., & Varigos, G. A. (2007). A low-glycemic-load diet improves symptoms in acne vulgaris patients: A randomized controlled trial. American Journal of Clinical Nutrition, 86(1), 107–115. https://doi.org/10.1093/ajcn/86.1.107
- Melnik, B. C., & Schmitz, G. (2009). Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. In Experimental Dermatology (Vol. 18, Issue 10, pp. 833–841). Exp Dermatol. https://doi.org/10.1111/j.1600-0625.2009.00924.x
- Cordain, L. (2005). Implications for the role of diet in acne. In Seminars in Cutaneous Medicine and Surgery (Vol. 24, Issue 2, pp. 84–91). Semin Cutan Med Surg. https://doi.org/10.1016/j.sder.2005.04.002
- Bowe, W. P., Joshi, S. S., & Shalita, A. R. (2010). Diet and acne. In Journal of the American Academy of Dermatology (Vol. 63, Issue 1, pp. 124–141). J Am Acad Dermatol. https://doi.org/10.1016/j.jaad.2009.07.043
- Smith, R. N., Mann, N. J., Braue, A., Mäkeläinen, H., & Varigos, G. A. (2007). The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: A randomized, investigator-masked, controlled trial. Journal of the American Academy of Dermatology, 57(2), 247–256. https://doi.org/10.1016/j.jaad.2007.01.046
- Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N. (2007). The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutrition and Metabolism, 4. https://doi.org/10.1186/1743-7075-4-5
- Schmidt, M., Pfetzer, N., Schwab, M., Strauss, I., & Kämmerer, U. (2011). Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. Nutrition and Metabolism, 8(1). https://doi.org/10.1186/1743-7075-8-54
- NEBELING, L. C., & LERNER, E. (1995). Implementing A Ketogenic Diet Based on Medium-chain Triglyceride Oil in Pediatric Patients with Cancer. Journal of the American Dietetic Association, 95(6), 693–697. https://doi.org/10.1016/S0002-8223(95)00189-1
- Nebeling, L. C., Miraldi, F., Shurin, S. B., & Lerner, E. (1995). Effects of a Ketogenic Diet on Tumor Metabolism and Nutritional Status in Pediatrie Oncology Patients: Two Case Reports. Journal of the American College of Nutrition, 14(2), 202–208. https://doi.org/10.1080/07315724.1995.10718495
- Fine, E. J., Segal-Isaacson, C. J., Feinman, R. D., Herszkopf, S., Romano, M. C., Tomuta, N., Bontempo, A. F., Negassa, A., & Sparano, J. A. (2012). Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients. Nutrition, 28(10), 1028–1035. https://doi.org/10.1016/j.nut.2012.05.001
- Klement, R. J., & Kämmerer, U. (2011). Is there a role for carbohydrate restriction in the treatment and prevention of cancer? In Nutrition and Metabolism (Vol. 8). Nutr Metab (Lond). https://doi.org/10.1186/1743-7075-8-75
- Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. In Cell (Vol. 144, Issue 5, pp. 646–674). Cell. https://doi.org/10.1016/j.cell.2011.02.013
- Giovannucci, E., Harlan, D. M., Archer, M. C., Bergenstal, R. M., Gapstur, S. M., Habel, L. A., Pollak, M., Regensteiner, J. G., & Yee, D. (2010). Diabetes and Cancer: A Consensus Report. CA: A Cancer Journal for Clinicians, 60(4), 207–221. https://doi.org/10.3322/caac.20078
- Denley, A., Carroll, J. M., Brierley, G. V., Cosgrove, L., Wallace, J., Forbes, B., & Roberts, C. T. (2007). Differential Activation of Insulin Receptor Substrates 1 and 2 by Insulin-Like Growth Factor-Activated Insulin Receptors. Molecular and Cellular Biology, 27(10), 3569–3577. https://doi.org/10.1128/mcb.01447-06
- Bistrian, B. R., Blackburn, G. L., Flatt, J. P., Sizer, J., Scrimshaw, N. S., & Sherman, M. (1976). Nitrogen metabolism and insulin requirements in obese diabetic adults on a protein sparing modified fast. Diabetes, 25(6), 494–504. https://doi.org/10.2337/diab.25.6.494
- Gumbiner, B., Wendel, J. A., & McDermott, M. P. (1996). Effects of diet composition and ketosis on glycemia during very-low-energy-diet therapy in obese patients with non-insulin-dependent diabetes mellitus. American Journal of Clinical Nutrition, 63(1), 110–115. https://doi.org/10.1093/ajcn/63.1.110
- Volek, J. S., Phinney, S. D., Forsythe, C. E., Quann, E. E., Wood, R. J., Puglisi, M. J., Kraemer, W. J., Bibus, D. M., Fernandez, M. L., & Feinman, R. D. (2009). Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids, 44(4), 297–309. https://doi.org/10.1007/s11745-008-3274-2
- Gumbiner, B., Wendel, J. A., & McDermott, M. P. (1996). Effects of diet composition and ketosis on glycemia during very-low-energy-diet therapy in obese patients with non-insulin-dependent diabetes mellitus. American Journal of Clinical Nutrition, 63(1), 110–115. https://doi.org/10.1093/ajcn/63.1.110
- Wilson, J. M., Lowery, R. P., Joy, J. M., Andersen, J. C., Wilson, S. M. C., Stout, J. R., Duncan, N., Fuller, J. C., Baier, S. M., Naimo, M. A., & Rathmacher, J. (2014). The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: A randomized, double-blind, placebo-controlled study. European Journal of Applied Physiology, 114(6), 1217–1227. https://doi.org/10.1007/s00421-014-2854-5
- Rauch, J. T., Silva, J. E., Lowery, R. P., McCleary, S. A., Shields, K. A., Ormes, J. A., Sharp, M. H., Weiner, S. I., Georges, J. I., Volek, J. S., D’agostino, D. P., & Wilson, J. M. (2014). The effects of ketogenic dieting on skeletal muscle and fat mass. Journal of the International Society of Sports Nutrition, 11(1), P40. https://doi.org/10.1186/1550-2783-11-S1-P40
- Volek, J. S., Sharman, M. J., Love, D. M., Avery, N. G., Gómez, A. L., Scheett, T. P., & Kraemer, W. J. (2002). Body composition and hormonal responses to a carbohydrate-restricted diet. Metabolism: Clinical and Experimental, 51(7), 864–870. https://doi.org/10.1053/meta.2002.32037
- Lambert, C. P., Frank, L. L., & Evans, W. J. (2004). Macronutrient considerations for the sport of bodybuilding. In Sports Medicine (Vol. 34, Issue 5, pp. 317–327). Sports Med. https://doi.org/10.2165/00007256-200434050-00004
- Lane, A. R., Duke, J. W., & Hackney, A. C. (2010). Influence of dietary carbohydrate intake on the free testosterone: Cortisol ratio responses to short-term intensive exercise training. European Journal of Applied Physiology, 108(6), 1125–1131. https://doi.org/10.1007/s00421-009-1220-5
- Fetterman, A. R. B., & Haldeman-Englert, C. M. (n.d.). Free Testosterone - Health Encyclopedia - University of Rochester Medical Center. Retrieved October 27, 2020, from https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=testosterone_free
- Lane, A. R., Duke, J. W., & Hackney, A. C. (2010). Influence of dietary carbohydrate intake on the free testosterone: Cortisol ratio responses to short-term intensive exercise training. European Journal of Applied Physiology, 108(6), 1125–1131. https://doi.org/10.1007/s00421-009-1220-5
- Creer, A., Gallagher, P., Slivka, D., Jemiolo, B., Fink, W., & Trappe, S. (2005). Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle. Journal of Applied Physiology, 99(3), 950–956. https://doi.org/10.1152/japplphysiol.00110.2005
- Noakes, M., Foster, P. R., Keogh, J. B., James, A. P., Mamo, J. C., & Clifton, P. M. (2006). Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk. Nutrition and Metabolism, 3. https://doi.org/10.1186/1743-7075-3-7
- Denne, S. C., Liechty, E. A., Liu, Y. M., Brechtel, G., & Baron, A. D. (1991). Proteolysis in skeletal muscle and whole body in response to euglycemic hyperinsulinemia in normal adults. American Journal of Physiology - Endocrinology and Metabolism, 261(6 24-6). https://doi.org/10.1152/ajpendo.1991.261.6.e809
- Gelfand, R. A., & Barrett, E. J. (1987). Effect of physiologic hyperinsulinemia on skeletal muscle protein synthesis and breakdown in man. Journal of Clinical Investigation, 80(1), 1–6. https://doi.org/10.1172/JCI113033
- Howarth, K. R., Phillips, S. M., MacDonald, M. J., Richards, D., Moreau, N. A., & Gibala, M. J. (2010). Effect of glycogen availability on human skeletal muscle protein turnover during exercise and recovery. Journal of Applied Physiology, 109(2), 431–438. https://doi.org/10.1152/japplphysiol.00108.2009
- Wolfe, R. R. (2006). Skeletal muscle protein metabolism and resistance exercise. Journal of Nutrition, 136(2). https://doi.org/10.1093/jn/136.2.525s
- Tipton, K. D., & Wolfe, R. R. (2001). Exercise, protein metabolism, and muscle growth. International Journal of Sport Nutrition, 11(1), 109–132. https://doi.org/10.1123/ijsnem.11.1.109
- Chargé, S. B. P., & Rudnicki, M. A. (2004). Cellular and Molecular Regulation of Muscle Regeneration. In Physiological Reviews (Vol. 84, Issue 1, pp. 209–238). Physiol Rev. https://doi.org/10.1152/physrev.00019.2003
- Rasmussen, B. B., & Phillips, S. M. (2003). Contractile and nutritional regulation of human muscle growth. In Exercise and Sport Sciences Reviews (Vol. 31, Issue 3, pp. 127–131). Lippincott Williams and Wilkins. https://doi.org/10.1097/00003677-200307000-00005
- Chargé, S. B. P., & Rudnicki, M. A. (2004). Cellular and Molecular Regulation of Muscle Regeneration. In Physiological Reviews (Vol. 84, Issue 1, pp. 209–238). Physiol Rev. https://doi.org/10.1152/physrev.00019.2003
- Miller, S. L., & Wolfe, R. R. (1999). Physical exercise as a modulator of adaptation to low and high carbohydrate and low and high fat intakes. European Journal of Clinical Nutrition, 53, s112–s119. https://doi.org/10.1038/sj.ejcn.1600751
- Jornayvaz, F. R., Samuel, V. T., & Shulman, G. I. (2010). The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. In Annual Review of Nutrition (Vol. 30, pp. 273–290). Annu Rev Nutr. https://doi.org/10.1146/annurev.nutr.012809.104726
- Naude, C. E., Schoonees, A., Senekal, M., Young, T., Garner, P., & Volmink, J. (2014). Low carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: A systematic review and meta-analysis. In PLoS ONE (Vol. 9, Issue 7). Public Library of Science. https://doi.org/10.1371/journal.pone.0100652
- Johnston, C. S., Tjonn, S. L., Swan, P. D., White, A., Hutchins, H., & Sears, B. (2006). Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. American Journal of Clinical Nutrition, 83(5), 1055–1061. https://doi.org/10.1093/ajcn/83.5.1055
- Thomson, C. A., Stopeck, A. T., Bea, J. W., Cussler, E., Nardi, E., Frey, G., & Thompson, P. A. (2010). Changes in body weight and metabolic indexes in overweight breast cancer survivors enrolled in a randomized trial of low-fat vs. reduced carbohydrate diets. Nutrition and Cancer, 62(8), 1142–1152. https://doi.org/10.1080/01635581.2010.513803
- Sacks, F. M., Bray, G. A., Carey, V. J., Smith, S. R., Ryan, D. H., Anton, S. D., McManus, K., Champagne, C. M., Bishop, L. M., Laranjo, N., Leboff, M. S., Rood, J. C., de Jonge, L., Greenway, F. L., Loria, C. M., Obarzanek, E., & Williamson, D. A. (2009). Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates. New England Journal of Medicine, 360(9), 859–873. https://doi.org/10.1056/nejmoa0804748
- Phillips, S. A., Jurva, J. W., Syed, A. Q., Syed, A. Q., Kulinski, J. P., Pleuss, J., Hoffmann, R. G., & Gutterman, D. D. (2008). Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension, 51(2), 376–382. https://doi.org/10.1161/HYPERTENSIONAHA.107.101824
- Samaha, F. F., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, T., Williams, M., Gracely, E. J., & Stern, L. (2003). A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity. New England Journal of Medicine, 348(21), 2074–2081. https://doi.org/10.1056/nejmoa022637
- Volek, J. S., Sharman, M. J., Gómez, A. L., Judelson, D. A., Rubin, M. R., Watson, G., Sokmen, B., Silvestre, R., French, D. N., & Kraemer, W. J. (2004). Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women. Nutrition and Metabolism, 1, 13. https://doi.org/10.1186/1743-7075-1-13
- Yancy, W. S., Olsen, M. K., Guyton, J. R., Bakst, R. P., & Westman, E. C. (2004). A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet to Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial. Annals of Internal Medicine, 140(10). https://doi.org/10.7326/0003-4819-140-10-200405180-00006
- Osterberg, K. L., Pallardy, S. E., Johnson, R. J., & Horswill, C. A. (2010). Carbohydrate exerts a mild influence on fluid retention following exercise-induced dehydration. Journal of Applied Physiology, 108(2), 245–250. https://doi.org/10.1152/japplphysiol.91275.2008
- Sherman, W. M., Costill, D. L., Fink, W. J., & Miller, J. M. (1981). Effect of exercise-diet manipulation on muscle glycogen and its subsequent utilization during performance. International Journal of Sports Medicine, 2(2), 114–118. https://doi.org/10.1055/s-2008-1034594
- Jensen, J., Rustad, P. I., Kolnes, A. J., & Lai, Y. C. (2011). The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. In Frontiers in Physiology: Vol. 2 DEC. Front Physiol. https://doi.org/10.3389/fphys.2011.00112
- Acheson, K. J., Schutz, Y., Bessard, T., Anantharaman, K., Flatt, J. P., & Jequier, E. (1988). Glycoprotein storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. American Journal of Clinical Nutrition, 48(2), 240–247. https://doi.org/10.1093/ajcn/48.2.240
- Kreitzman, S. N., Coxon, A. Y., & Szaz, K. F. (1992). Glycogen storage: Illusions of easy weight loss, excessive weight regain, and distortions in estimates of body composition. American Journal of Clinical Nutrition, 56(1 SUPPL.). https://doi.org/10.1093/ajcn/56.1.292S
- Feinman, R. D., Pogozelski, W. K., Astrup, A., Bernstein, R. K., Fine, E. J., Westman, E. C., Accurso, A., Frassetto, L., Gower, B. A., McFarlane, S. I., Nielsen, J. V., Krarup, T., Saslow, L., Roth, K. S., Vernon, M. C., Volek, J. S., Wilshire, G. B., Dahlqvist, A., Sundberg, R., … Worm, N. (2015). Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. In Nutrition (Vol. 31, Issue 1, pp. 1–13). Elsevier Inc. https://doi.org/10.1016/j.nut.2014.06.011
- Barañano, K. W., & Hartman, A. L. (2008). The ketogenic diet: Uses in epilepsy and other neurologic illnesses. In Current Treatment Options in Neurology (Vol. 10, Issue 6, pp. 410–419). Curr Treat Options Neurol. https://doi.org/10.1007/s11940-008-0043-8
- Walker, L., & Sills, G. J. (2012). Inflammation and epilepsy: The foundations for a new therapeutic approach in epilepsy? In Epilepsy Currents (Vol. 12, Issue 1, pp. 8–12). American Epilepsy Society. https://doi.org/10.5698/1535-7511-12.1.8
- Lowenstein, D. H. (2009). Epilepsy after head injury: An overview. Epilepsia, 50(SUPPL. 2), 4–9. https://doi.org/10.1111/j.1528-1167.2008.02004.x
- Allen, A. S., Berkovic, S. F., Cossette, P., Delanty, N., Dlugos, D., Eichler, E. E., Epstein, M. P., Glauser, T., Goldstein, D. B., Han, Y., Heinzen, E. L., Hitomi, Y., Howell, K. B., Johnson, M. R., Kuzniecky, R., Lowenstein, D. H., Lu, Y. F., Madou, M. R. Z., Marson, A. G., … Winawer, M. R. (2013). De novo mutations in epileptic encephalopathies. Nature, 501(7466), 217–221. https://doi.org/10.1038/nature12439