Fortify | Joint Support
IT’S-ON-US MONEY-BACK GUARANTEE
Many companies offer a money-back guarantee because they know the majority of dissatisfied customers aren’t going to go through the hassle of actually returning the product to get their money back. We don’t play these games because we don’t have to, the quality of our products makes it unnecessary.
If you order any of our supplements for the first time and don’t like it, you can keep it. Just notify us and we’ll give you a full refund on the spot. No complicated forms and no return necessary.
To protect ourselves from fraud, the It’s-On-Us guarantee is only valid for first time purchases of a product, and redeemable up to three months after purchase. If you bought more than one bottle of a supplement on your first purchase and don’t like it, we would ask that you send the unopened bottles back to us for a refund because we can put them back into our sellable inventory.
FORTIFY contains 100% natural, safe substances that are scientifically proven to improve joint health, reduce pain and inflammation, and protect against disease and dysfunction.
While our choices of ingredients alone set FORTIFY apart from the rest of the crowd, what really proves its superiority is that each ingredient is included at clinically effective dosages.
That means that the dosages of each ingredient in FORTIFY are based on published scientific research proving joint health benefits, not the restrictions of razor-thin production budgets or gluttonous profit margins.
When you start comparing actual numbers, you will quickly see that one serving of FORTIFY contains about two to three times the amount of effective ingredients as our best competitors’ products.
While everyone claims to have the best joint supplements on the market, we believe we can actually back up such a claim with real science and real numbers.
If you want healthy, functional, and pain-free joints that can withstand the demands of your active lifestyle and even the toughest training...then you want to try FORTIFY today.
“An ounce of prevention is worth a pound of cure.”
Ben Franklin once said that famous line and it has a lot of relevance to us physically active folks, especially to athletes and weightlifters.
People will rush to buy muscle builders, protein powders, hormone boosters, fat burners, and the like, but they often overlook products designed to improve general function and longevity.
Well, anybody that has spent years training hard knows how vitally important healthy joints are.
More than 52 million Americans suffer from arthritis, and if your joints are inflamed or damaged, all aspects of your performance decline.  For example, you may lose speed, strength, power, and agility; you may not be able to do certain exercises and activities; you may not be able to handle weights you once could; and you likely have to learn to deal with constant, nagging aches and pains.
Healthy joints are one of those things people just don’t fully appreciate until they’re gone.
Supporting joint health starts with proper training, nutrition, and rest, but supplementation can help greatly as well (and is particularly effective in rehabilitation).
You see, your joints are lined with a flexible tissue known as cartilage, which lubricates them and absorbs physical impacts. Healthy cartilage preserves ease of motion and keeps your joints pain free.
Many people assume that regular exercise must accelerate cartilage loss through repetitive use and general wear and tear. Research shows otherwise, though.
Forms of exercise usually assumed to be harmful to your joints like weightlifting and long-distance running are not associated with cartilage loss or osteoarthritis. In fact, regular exercise appears to help preserve healthy cartilage levels.
Why, then, do so many long-term exercisers and athletes seem to suffer from joint problems? And what can be done about it?
Well, to answer those questions, let’s take a closer look at how joints lose their structural integrity, eventually resulting in arthritis.
Two common forms of arthritis are osteoarthritis and rheumatoid arthritis, which involve painful inflammation of the joints resulting from the gradual loss of the cartilage.
Osteoarthritis has been long believed to be a natural consequence of aging, and rheumatoid arthritis is an autoimmune disease that results in joint inflammation and destruction.
Well, we now know that both conditions are at least partially caused by an unwanted destructive immune response to joint collagen that eats away at the joints.
What happens is your body’s immune system incorrectly targets and attacks joint cartilage as a foreign, unwanted substance.
Theoretically, then, if we could stop this internal assault on your joints as well as reduce existing joint inflammation, we could dramatically improve your joint health and reduce the risk of disease and dysfunction.
And that’s exactly what research suggests.
Studies show that, in people with arthritic conditions, reducing inflammation and “teaching” the immune system to stop attacking proteins found in joint cartilage can significantly improve joint health and function and decrease or even eliminate pain and swelling. 
And that’s why we created FORTIFY.
Its formulation is the result of an extensive scientific review of a wide variety of natural molecules known to support joint health.
We carefully chose a handful that work synergistically to safely deliver consistent results in regulating the immune response that destroys the joints and reducing the inflammation that causes pain and swelling.
The result is the most powerful joint supplement available for improving joint health, function, and longevity, with every ingredient backed by sound clinical research and included at clinically effective dosages.
Let’s take a look at the formulation.
Uc II® Undenatured Type UC-II Collagen
Collagen is the main protein of the various connective tissues in animals and type II collagen (CII) is a type of collagen that makes up your joint cartilage.
“Undenatured” is more than a fancy word—it’s vitally important to the effectiveness of the product.
Denaturization is the alteration of the natural structure of a substance, usually by the addition of another chemical or heat that changes the substance’s physical properties.
Typical commercial processing of collagen causes alterations to its basic form (denaturization), and research shows that denatured collagen has no beneficial effects on joint inflammation.
Undenatured collagen, however, is a more natural form of the substance and research shows that the UC II® undenatured type II collagen is highly effective for regulating the immune response that inflames joints and destroys cartilage and bone, which further inflames the joints and starts a degenerative cycle. 
And the best part about undenatured type II collagen is that these effects have been demonstrated in people with arthritic conditions and people with healthy joints.
It accomplishes this by “teaching” the body’s immune system to stop attacking collagen as a foreign substance, which is the cause of some arthritic conditions. Orally ingesting CII works almost like a vaccine, resulting in less of an inflammatory response to your own collagen because the body now recognizes it.
The clinically effective dosages of undenatured type II collagen range between 10 and 40 milligrams.
FORTIFY CONTAINS 10 MG OF UNDENATURED TYPE II COLLAGEN PER SERVING
We chose the lower end of the clinically effective dosage because it isn’t clear if more is better. Research clearly shows that 10 mg is effective but not that two, three, or four times that amount is more so.
Curcumin & Piperine
Curcumin is the yellow pigment found in the turmeric plant, which is the main spice in curry. It has been used therapeutically in Ayurvedic medicine for thousands of years.
Its health benefits are extensive and scientific researchers around the world are investigating applications for fighting a variety of disease such as cancer, cardiovascular disease, osteoporosis, diabetes, Alzheimer’s, and more.
One reason for this is that curcumin has powerful anti-inflammatory effects, which are exerted by inhibiting proteins that trigger the production of inflammatory chemicals.
Curcumin has a significant downside, however: intestinal absorption is very poor.  So much so that supplementation without enhancement more or less eliminates the majority of its health benefits.
Fortunately, there’s an easy solution for increasing bioavailability—black pepper extract. Research shows that pairing black pepper extract with curcumin increases bioavailability twentyfold. And when you do that, curcumin becomes an effective joint support supplement.
Studies show that supplementation with curcumin and black pepper extract reduces inflammatory signals in the joints and, in those with arthritis, relieves pain and stiffness and improves mobility.
When paired with piperine, the clinically effective dosages of curcumin range between 200 and 500 milligrams.
FORTIFY CONTAINS 500 MG OF CURCUMIN AND 20 MG OF PIPERINE PER SERVING
Boswellia serrata is a plant that produces an aromatic substance known as frankinsence, which has been used for thousands of years in Ayurvedic medicine to treat various disorders related to inflammation.
Thanks to modern science, we now know why.
Frankinsence contains molecules known as boswellic acids. Research shows that, like curcumin, boswellic acids—and one in particular known as acetyl-keto-beta-boswellic acid, or AKBA—inhibit the production of several proteins that cause inflammation in the body. 
And in case you’re wondering, the difference between the anti-inflammatory mechanisms of curcumin and boswellic acids is they work on different enzymes. Curcumin inhibits an enzyme known as cyclooxygenase, or COX, and boswellic acids inbhibit lysyl oxidase, or LOX (and, most notably, 5-LOX).
These anti-inflammatory properties extend to the joints, which is why studies show that Boswellia serrata is an effective treatment for reducing joint inflammation and pain as well as inhibiting the autoimmune response that eats away at joint cartilage and eventually causes arthritis. 
The clinically effective dosages of boswellia serrata range between 100 and 200 milligrams.
FORTIFY CONTAINS 150 MG OF BOSWELLIA SERRATA (PROVIDING 30 MG OF AKBA) PER SERVING
Grape Seed Extract
Grape seed extract is a substance derived from the ground-up seeds of red wine grapes, which have been used in European medicine for thousands of years.
There are two molecules in grape seed extract that account for most of its health benefits: tannins, which are bitter compounds that make wine taste dry, and procyanidins, which are chains of antioxidants found in some plants.
Much of the research on grape seed extract’s beneficial effects on joint health is extrapolated from research on a similar molecule known as pycnogenol, which is also a potent source of procyanidins. Pycnogenol is significantly more expensive than grape seed extract, however, which is why GSE is preferable for supplementation needs.
Research shows that the primary way grape seed extract helps protect joint cartilage from damage caused by the pro-inflammatory immune response that can develop into arthritis.
Studies also show that supplementation with grape seed extract confers other health benefits, including the following:
- Better eye health 
- A reduced risk of heart disease 
- Greater blood glucose control 
- Improved blood flow to the extremities, which can reduce the appearance of varicose veins  and
- Potential anti-cancer activities 
Clinically effective dosages of grape seed extract range from 75 to 300 mg.
FORTIFY CONTAINS 90 MG OF GRAPE SEED EXTRACT PER SERVING
STILL HAVE QUESTIONS?
Ingredients & Use
Take 2 capsules daily, with or without meals. For optimal results, take first thing in the morning.
Check with a qualified healthcare professional before using this product if you are under 18 years of age or if you have any pre-existing medical conditions and/or are taking any prescription medication(s).
KEEP OUT OF REACH OF CHILDREN. STORE IN A COOL, DRY PLACE. DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.
Legion has the best fans in the world,
and we're proud to share their photos with you!
Blackwell DL, Lucas JW, Clarke TC. Summary health statistics for U.S. adults: National Health Interview Survey, 2012. National Center for Health Statistics. Vital Health Stat 10(260). 2014. ↑
F. Eckstein1, M. Hudelmaier1 andR. Putz2 Article first published online: 18 APR 2006 DOI: 10.1111/j.1469-7580.2006.00546.x ↑
Chakravarty EF1, Hubert HB, Lingala VB, Zatarain E, Fries JF. Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA. ↑
Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Int J Clin Pharmacol Res. 2002;22(3-4):101-10. ↑
Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Int J Med Sci. 2009 Oct 9;6(6):312-21. ↑
Cathryn Nagler-Anderson, Loretta A. Bober, M. Elizabeth Robinson, Gregory W. Siskind, and G. Jeanette Thorbecke, “Suppression of Type II Collagen-Induced Arthritis by Intragastric Administration of Soluble Type II Collagen,” Proceedings of the National Academy of Sciences 83, no. 19 (1986): 7443–46. ↑
Lugo JP, Saiyed ZM, Lau FC, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition. 2013;10:48. doi:10.1186/1550-2783-10-48. ↑
Bayrak Ş, Mitchison NA. Bystander suppression of murine collagen-induced arthritis by long-term nasal administration of a self type II collagen peptide. Clinical and Experimental Immunology. 1998;113(1):92-95. doi:10.1046/j.1365-2249.1998.00638.x. ↑
Bharat B. Aggarwal, Chitra Sundaram, Nikita Malani, and Haruyo Ichikawa, “Curcumin: The Indian Solid Gold,” Advances in Experimental Medicine and Biology 595 (2007): 1–75. ↑
Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K. Sandur, Shishir Shishodia, and Bharat B. Aggarwal, “Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation,” Molecular Pharmacology 69, no. 1 (2006): 195–206. doi: 10.1124/mol.105.017400. ↑
Preetha Anand, Ajaikumar B. Kunnumakkara, Robert A. Newman, and Bharat B. Aggarwal, “Bioavailability of Curcumin: Problems and Promises,” Molecular Pharmaceutics 4, no. 6 (2007): 807–18. doI: 10.1021/mp700113r. ↑
Garcea G, Berry DP, Jones DJ, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5. ↑
Guido Shoba, David Joy, Thangam Joseph, Muhammed Majeed, Rajesh Rajendran, and Priya S. S. R. Srinivas, “Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers,” Pharmacology 64, no. 4 (1998): 353–56. doi: 10.1055/s-2006-957450. ↑
John K. Jackson, Tobi Higo, William L. Hunter, and Helen M. Burt, “The Antioxidants Curcumin and Quercetin Inhibit Inflammatory Processes Associated with Arthritis,” Inflammation Research 55, no. 4 (2006): 168–75; Gianni Belcaro, Maria Rosaria Cesarone, Mark Dugall, Luciano Pellegrini, Andrea Ledda, Maria Giovanna Grossi, Stefano Togni, and Giovanni Appendino, “Efficacy and Safety of Meriva, a Curcumin-Phosphatidylcholine Complex, during Extended Administration in Osteoarthritis Patients,” Alternative Medicine Review 15, no. 4 (2010): 337–44. ↑
Muhammad Zain Siddiqui, “Boswellia serrata, a Potential Anti-Inflammatory Agent: An Overview,” Indian Journal of Pharmaceutical Sciences 73, no. 3 (2011): 255–61. doi: 10.4103/0250-474X.93507. ↑
Eckart-Roderich Sailer, Lakshminarayanapuram R. Subramanian, Beatrice Rall, Rainer F. Hoernlein, Hermann P. T. Ammon, and Hasan Safayhi, “Acetyl-11-keto-beta-Boswellic Acid (AKBA): Structure Requirements for Binding and 5-lipoxygenase Inhibitory Activity,” British Journal of Pharmacology 117, no. 4 (1996): 615–18. ↑
N. Kimmatkar, Vijay Thawani, Lal Hingorani, and R. Khiyani, “Efficacy and Tolerability of Boswellia serrata Extract in Treatment of Osteoarthritis of Knee—A Randomized Double Blind Placebo Controlled Trial,” Phytomedicine 10, no. 1 (2003): 3–7l; Hermann P. T. Ammon, “Boswellic Acids in Chronic Inflammatory Diseases,” Planta Medica 72, no. 12 (2006): 1100–16. doi: 10.1055/s-2006-947227. ↑
Komal Raina, Alpna Tyagi, Dileep Kumar, Rajesh Agarwal, and Chapla Agarwal, “Role of Oxidative Stress in Cytotoxicity of Grape Seed Extract in Human Bladder Cancer Cells,” Food and Chemical Toxicology 61 (2013): 187–95. doi: 10.1016/j.fct.2013.06.039. ↑
Hongseok Yang, Bo Kyung Lee, Koung Hoon Kook, Yi-Sook Jung, and Jaehong Ahn, “Protective Effect of Grape Seed Extract against Oxidative Stress-Induced Cell Death in a Staurosporine-Differentiated Retinal Ganglion Cell Line,” Current Eye Research 37, no. 4 (2012): 339–44. doi:10.3109/02713683.2011.645106. ↑
Beata Olas, Barbara Wachowicz, Anna Stochmal, and Wiesław Oleszek, “The Polyphenol-Rich Extract from Grape Seeds Inhibits Platelet Signaling Pathways Triggered by Both Proteolytic and Non-Proteolytic Agonists,” Platelets 23, no. 4 (2012): 282–89. doi:10.3109/09537104.2011.618562; Harm H. H. Feringa, Dayne A. Laskey, Justine E. Dickson, and Craig I. Coleman, “The Effect of Grape Seed Extract on Cardiovascular Risk Markers: A Meta-Analysis of Randomized Controlled Trials,” Journal of the Academy of Nutrition and Dietetics 111, no. 8 (2011): 1173–81. ↑
Suwimol Sapwarobol, Sirichai Adisakwattana, Sawitree Changpeng, Wilwan Ratanawachirin, Kanokporn Tanruttanawong, and Waridtha Boonyarit, “Postprandial Blood Glucose Response to Grape Seed Extract in Healthy Participants: A Pilot Study,” Pharmacognosy Magazine 8, no. 3 (2012): 192–96. doi: 10.4103/0973-1296.99283. ↑
Atsushi Sano, Shoichi Tokutake, and Akihiko Seo, “Proanthocyanidin-Rich Grape Seed Extract Reduces Leg Swelling in Healthy Women during Prolonged Sitting,” Journal of the Science of Food and Agriculture 93, no. 3 (2013): 457–62. doi: 10.1002/jsfa.5773. ↑
Simona Dinicola, Alessia Pasqualato, Alessandra Cucina, Pierpaolo Coluccia, Francesca Ferranti, Rita Canipari, Angela Catizone, Sara Proietti, Fabrizio D’Anselmi, Giulia Ricci, Alessandro Palombo, and Mariano Bizzarri, “Grape Seed Extract Suppresses MDA-MB231 Breast Cancer Cell Migration and Invasion,” European Journal of Nutrition 53, no. 2 (2014): 421–31; Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Alba Macià, Mayte Blay, Anna Ardévol, Maria-José Motilva, and Montserrat Pinent, “Gallic Acid Is an Active Component for the Anticarcinogenic Action of Grape Seed Procyanidins in Pancreatic Cancer Cells,” Nutrition and Cancer 66, no. 1 (2014): 88–96. doi:10.1080/01635581.2014.851714; Komal Raina, Alpna Tyagi, Dileep Kumar, Rajesh Agarwal, and Chapla Agarwal, “Role of Oxidative Stress in Cytotoxicity of Grape Seed Extract in Human Bladder Cancer Cells,” Food and Chemical Toxicology 61 (2013): 187–95. doi: 10.1016/j.fct.2013.06.039. ↑