Energy Drink with Organic Caffeine

Q: How do I use your energy drink?

Drink whenever you want a boost in mental and physical performance, especially before a workout.

Q: Will your energy drink improve my energy?

Yes. Our energy drink contains clinically effective doses of caffeine, L-theanine, CDP-choline, taurine, and B vitamins, which are proven to boost focus, energy, power, strength, and stamina.

Q: Can I drink your energy drink every day?

Yes. It’s sensible to occasionally “cycle” off supplements containing stimulants because it helps you maintain sensitivity to the ingredients and prevents unwanted side effects that some people experience with long-term stimulant use. That said, our energy drink only contains a moderate dose of caffeine (150 mg), which means most people should be able to take it every day or even multiple times per day without issue or “cycling” off.

Q: Can I take your energy drink with other Legion supplements?

Yes. We’ve formulated our energy drink to work in conjunction with other Legion supplements like Pulse, Phoenix, and Energy Surge, which also contain caffeine. That said, everyone’s tolerance for caffeine is different—some people can tolerate only very small doses or none at all without unwanted effects, while others can consume larger amounts without negative side effects (sleep disturbance, jitters, etc.). If you regularly consume caffeine from other sources like Pulse pre-workout, coffee, or tea, you may want to reduce or eliminate your intake from other sources to “make room” for the caffeine in this product. If you aren’t used to consuming caffeine, you may want to start with 1 serving (can) per day and see how you feel before consuming more. In either case, you’ll need to experiment with varying doses to see what works best for your body.

Q: Does your energy drink have any side effects?

All of the ingredients in our energy drink are generally safe and well tolerated.

Q: Can your energy drink be taken while pregnant or breastfeeding?

While we’re not aware of any reasons it would be harmful, check with your doctor before taking this product.

Q: Can your energy drink be taken with medication?

While there are very few negative interactions between the ingredients in our energy drink and medications, there may be some, and thus you should always talk to your doctor if you’re currently taking medication and want to consider taking this product.

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Our "No Return Necessary"
Money-Back Guarantee

If you don’t like something of ours, guess what happens next?

No, we don’t request you deliver it to a PO box in the Gobi Desert by carrier pigeon. Nor do we ask you to fill a cursed inkwell with orc’s blood and demon saliva and then use it to complete reams of return forms written in ancient Cyrillic script.

We just . . . wait for it . . . give you your money back. Holy moo cows. And that means you can say "yes" now and decide later.

Will our energy drink supercharge your nervous system for explosive energy and maximum mental and physical performance?

No.

Will it crush fatigue and procrastination and give you an “unfair advantage” inside and outside of the gym?

Absolutely not.

But is it the only[1] Some popular energy drinks are naturally sweetened and flavored. Some contain the right mix of high-quality ingredients. Some provide clinically effective doses. But only our energy drink checks each of these boxes. naturally sweetened and flavored[2] While artificial sweeteners may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health. That’s why we use the natural sweeteners stevia, monk fruit, and erythritol instead. energy drink with clinically effective doses[3] Every serving of our energy drink contains 3.57 grams of active ingredients that have been shown to be safe and effective in peer-reviewed scientific research. of 8 ingredients scientifically proven[4] Each active ingredient in our energy drink is backed by published scientific studies that show benefits in healthy humans. to increase energy, focus, mood, and cognition?

And without the “caffeine crash” or other unwanted side effects?

Yes. Or your money back

40 peer-reviewed scientific studies support the effectiveness of our energy drink’s precise combination of ingredients and doses[5] That’s 402 pages of scientific research that shows our energy drink works exactly like we say it does.
Naturally sweetened and flavored with no artificial sweeteners, flavors, food dyes, fillers, or other unnecessary junk[6] While these types of chemicals may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health.
Analyzed for purity and potency in a state-of-the-art ISO 17025 accredited lab[7] Every can of our energy drink is guaranteed to provide exactly what the label claims and nothing else—no heavy metals, microbes, allergens, or other contaminants.
Clean and transparent label that shows exactly what’s in every serving and what’s not (no proprietary blends or hidden ingredients)[8] The "proprietary blend" is little more than a sneaky way to use tiny (ineffective) amounts of lots of ingredients and hope customers don't know any better.
Made in the USA with globally sourced ingredients in FDA-inspected facilities that adhere to Current Good Manufacturing Practice standards

Our energy drink is also backed by our “No Return Necessary” money-back guarantee that works like this:

If you don’t absolutely love it, just let us know, and we’ll give you a full refund on the spot. No forms or returns necessary.

So order now, try it risk free, and see for yourself why we believe it’s the perfect clean energy beverage.

Will our energy drink supercharge your nervous system for explosive energy and maximum mental and physical performance?

No.

Will it crush fatigue and procrastination and give you an “unfair advantage” inside and outside of the gym?

Absolutely not.

But is it the perfect alternative to coffee or pre-workout when you want a boost to get through a workout or afternoon slump?

And without the “caffeine crash” or other unwanted side effects?

Yes. Or your money back.

Clean and transparent label that shows exactly what’s in every serving and what’s not (no proprietary blends or hidden ingredients)[8] The "proprietary blend" is little more than a sneaky way to use tiny (ineffective) amounts of lots of ingredients and hope customers don't know any better.
Made in the USA with globally sourced ingredients in FDA-inspected facilities that adhere to Current Good Manufacturing Practice standards
Backed by our “No Return Necessary” money-back guarantee that works like this: If you don’t absolutely love our energy drink, just let us know, and we’ll give you a full refund on the spot. No forms or returns necessary.

So order now, try it risk free, and see for yourself why we believe it’s the perfect clean energy beverage.

Notice to California Consumers

WARNING: Consuming this product can expose you to chemicals including lead which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Legion Energy Drink Ingredients (3,577 milligrams per serving)

PurCaf® Natural and Organic Caffeine (150 milligrams per serving)

Caffeine is a naturally occurring substance found in many plants native to Africa, East Asia, and South America, including various kinds of tea, cocoa, and coffee.

PurCaf® is an organic, patented form of caffeine extracted from non-GMO green coffee beans using a proprietary clean-water process.

Naturally derived caffeine tastes significantly better than its synthetic counterpart, and anecdotally, many people report that it provides a "smoother" boost of energy, possibly due to beneficial compounds like chlorogenic acids and antioxidants found in natural caffeine but absent in synthetic versions.

Caffeine’s primary effects in the body are to stimulate the central nervous system and block the activity of another chemical—adenosine—that causes tiredness.

Research shows that supplementation with PurCaf® caffeine . . .

Boosts mood and energy levels[9]
Improves focus, drive, and wakefulness[10][11][12]
Increases metabolic rate[13]
Enhances strength and power[14][15][16][17][18]
Boosts endurance[19][20][21]
Improves anaerobic performance[22][23][24][25][26]

The clinically effective dose of caffeine for enhancing energy, focus, and performance is between 50 milligrams and 6 milligrams per kilogram of body weight.[27][28][29]

Suntheanine® L-Theanine (150 milligrams per serving)

L-theanine is an amino acid found primarily in tea that helps balance the levels of two chemicals in the brain—glutamate and GABA—that transmit nerve impulses and affect mood, cognitive performance, and more.

Suntheanine® is a patented form of L-theanine that’s the most clinically proven form on the market, with over 200 peer-reviewed studies supporting its efficacy.

Research shows that supplementation with Suntheanine® L-theanine . . .

Reduces the effects of mental stress[30]
Promotes relaxation[31]
Improves mood, memory performance, and attention (when paired with caffeine)[32][33][34][35]
Increases the production of nitric oxide (which improves blood flow)[36]

The clinically effective dose of L-theanine when combined with caffeine is between a ratio of 1:1 and 2:1 theanine to caffeine.

Cognizin® Citicoline (250 milligrams per serving)

Citicoline is a chemical that occurs naturally in the brain and increases levels of another chemical called phosphatidylcholine, which is vital for brain health and function.

Citicoline can also increase levels of a neurotransmitter known as acetylcholine, which is involved in learning and muscular contraction.

Cognizin® is a patented form of citicoline that’s the only form studied in healthy adults and supported by 16 years of clinical research.

Research shows that supplementation with Cognizin® citicoline . . .

Improves focus and memory[37][38]
Boosts attention and mental processing speed[39]
Mitigates cognitive decline as we age[40][41][42]

The clinically effective dose of citicoline is between 250 and 500 milligrams.

Taurine (2,000 milligrams per serving)

Taurine is an amino acid found primarily in seafood and meat that, unlike most amino acids, isn’t used to build proteins.

Rather, it plays an important role in cardiovascular and muscle function by protecting cells from oxidative stress and regulating the release of neurotransmitters.

Research shows that supplementation with taurine . . .

Improves focus, attention, and reasoning when combined with caffeine[43][44]
Helps minimize unwanted side effects of caffeine (like jitters)[45]
Helps prevent a “sugar crash” by slowing the release of glucose into the blood[46][47]

The clinically effective dose of taurine is 1-to-6 grams per day, with the majority of benefits in the range of ~1-to-3 grams.

B Vitamin Complex (27.4 milligrams per serving)

B vitamins are a category of naturally-occurring substances that cells need to turn food into energy. They also affect mood, feelings of wellness, and brain, nerve, and cardiovascular function.

Although B vitamins don’t directly increase energy levels in the same way as a stimulant like caffeine, many people report feeling more energized when supplementing with B vitamins. This is likely because B vitamins are required for many bodily processes that influence energy production, and thus, by increasing the availability of B vitamins, such processes can function more effectively.

Research shows that supplementation with B vitamins (particularly vitamins B2, B3, B6, and B12) . . .

Reduces stress[48]
Improves mental clarity, energy, and focus[49]
Boosts cognitive function and memory[50][51]
Improves mood and energy levels[52][53]

There is no established clinically effective dose of B vitamins, but the ones thought to most improve energy, mood, and cognitive function are B2, B3, B6, and B12 in the amounts contained in our energy drink.

Naturally Sweetened & Flavored

While artificial sweeteners may not be as dangerous as some people claim, studies suggest that regular consumption of these chemicals may indeed be harmful to our health.[54][55][56][57][58][59]

That’s why we use the natural sweeteners stevia and erythritol instead. Studies show that these ingredients are not only safe but can also confer several health benefits, including better nutrient absorption, healthy cholesterol and inflammation levels, and more.[60][61][62][63]

No Artificial Food Dyes or Other Chemical Junk

No Artificial Food Dyes, Fillers, or Other Unnecessary Junk

As with artificial sweeteners, artificial food dyes aren’t a hazard per se, but studies show they can cause negative effects in some people, including gastrointestinal toxicity and behavioral disorders.[64][65][66][67][68]

Lab Tested for Potency & Purity

Every can of our energy drink is analyzed in a state-of-the-art ISO 17025 accredited lab to verify what is and isn’t in it. That way, you know exactly what you’re getting and putting into your body.

See how Legion energy drinks compare to the rest.

Active Ingredients
Clinically Effective Ingredients & Doses
Caffeine
L-Theanine
Citicoline
Taurine
Vitamin B Complex
Naturally Sweetened & Flavored
Third-Party Lab Tested
Labdoor Certified Brand
Price Per Can

Legion
Energy Drink
3,577 mg
per serving
150 mg
per serving
150 mg
per serving
250 mg
per serving
2,000 mg
per serving
27.4 mg
per serving
$

Ghost
Energy
2,492 mg
per serving
200 mg
per serving
1,000 mg
per serving
17.7 mg
per serving
$2.50

Cellucor C4
Energy Drink
(proprietary blend)
A proprietary blend is a group of ingredients that lists their names but not amounts, making it impossible to know if the dosages are at clinically effective levels.
200 mg
per serving
36 mg
per serving
$2.33

Red Bull
Sugar Free
(proprietary blend)
A proprietary blend is a group of ingredients that lists their names but not amounts, making it impossible to know if the dosages are at clinically effective levels.
114 mg
per serving
(proprietary blend)
A proprietary blend is a group of ingredients that lists their names but not amounts, making it impossible to know if the dosages are at clinically effective levels.
31.85 mg
per serving
$2.13

The #1 brand of natural sports supplements.

5+ million bottles sold to 1+ million customers who have left us 45,000+ 5-star reviews.

Clinically Effective Ingredients & Doses

Every ingredient and dose in our energy drink is backed by peer-reviewed scientific research demonstrating clear benefits.

Naturally Sweetened & Flavored

Our energy drink contains no artificial sweeteners or flavors, food dyes, fillers, or other unnecessary junk.

100% Clean & Transparent Label

Our energy drink contains no hidden ingredients or proprietary blends, so you know exactly what (and what amount) is in every serving.

Third-Party Lab Tested

Our energy drink is tested by third-party labs for heavy metals, microbes, allergens, and other contaminants to ensure it meets FDA purity standards.

Made in the USA

Our energy drink is made in America with globally sourced ingredients in FDA-inspected facilities that adhere to Current Good Manufacturing Practice standards.

"No Return Necessary"
Money-Back Guarantee

If you don't absolutely love our energy drink, you get a prompt and courteous refund. No forms or returns necessary.

Trusted by scientists, doctors, and everyday fitness folk alike.

"Legion is science-based at its core. Not only do they dose all of their products based on the clinical doses proven to be effective by scientific studies, they go above and beyond the their competitors by funding new research."

Dr. Bill Campbell, PhD
Professor of Exercise Science at University of South Florida
"There are a lot of sleazy supplement companies out there, but Legion is not one of them. Their products are free of fillers and inactive ingredients and they take the time (and money) to test them with independent labs to ensure you're getting what you pay for."

Dr. Spencer Nadolsky, MD
Board-Certified Family Medicine Physician and a Diplomate of the American Board of Obesity Medicine
"When it comes to quality and integrity, Legion is among the best. Their products only include ingredients that are backed by research and in doses that are proven to be effective in scientific studies."

Sal Di Stefano, Justin Andrews, and Adam Schafer
Hosts of The Mind Pump Podcast
"Legion is a tremendous company run by people I trust and respect. The quality of their supplements is second to no one. And while I don’t use many supplements, the only ones I do come from Legion."

Jordan Syatt
Strength and Nutrition Coach
"Legion consults with nutrition experts to make honest, science-based products and then proves they're genuine with independent lab work. That's how all supplement companies should operate."

Menno Henselmans, MS
Founder of Bayesian Bodybuilding, Published Scientist, and Physique Coach
"Legion's customers are getting some of the best sports supplements on the market."
"Legion Pulse is the best overall pre-workout, especially for energy and focus."
"Legion Pulse is the best pre-workout of 2024."

Frequently Asked Questions

How do I use your energy drink?

Will your energy drink improve my energy?

Can I drink your energy drink every day?

Can I take your energy drink with other Legion supplements?

Does your energy drink have any side effects?

Can your energy drink be taken while pregnant or breastfeeding?

Can your energy drink be taken with medication?

Is your energy drink gluten-free? Soy-free? Dairy-free?

Is your energy drink vegetarian or vegan friendly?

+References

Some popular energy drinks are naturally sweetened and flavored. Some contain the right mix of high-quality ingredients. Some provide clinically effective doses. But only our energy drink checks each of these boxes.↑

While artificial sweeteners may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health. That’s why we use the natural sweeteners stevia, monk fruit, and erythritol instead.↑

Every serving of our energy drink contains 3.57 grams of active ingredients that have been shown to be safe and effective in peer-reviewed scientific research.↑

Each active ingredient in our energy drink is backed by published scientific studies that show benefits in healthy humans.↑

That’s 402 pages of scientific research that shows our energy drink works exactly like we say it does.↑

While these types of chemicals may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health.↑

Every can of our energy drink is guaranteed to provide exactly what the label claims and nothing else—no heavy metals, microbes, allergens, or other contaminants.↑

The "proprietary blend" is little more than a sneaky way to use tiny (ineffective) amounts of lots of ingredients and hope customers don't know any better.↑

9. Exercise and sport performance with low doses of caffeine.

Spriet LL. Sports Med. 2014;44 Suppl 2(Suppl 2):S175-S184. doi:10.1007/s40279-014-0257-8.↑

10. A review of caffeine's effects on cognitive, physical and occupational performance.

McLellan TM, Caldwell JA, Lieberman HR. Neurosci Biobehav Rev. 2016;71:294-312. doi:10.1016/j.neubiorev.2016.09.001.↑

11. Caffeine to optimize cognitive function for military mission-readiness: a systematic review and recommendations for the field.

Crawford C, Teo L, Lafferty L, et al. Nutr Rev. 2017;75(suppl_2):17-35. doi:10.1093/nutrit/nux007.↑

12. Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep.

Kamimori GH, McLellan TM, Tate CM, Voss DM, Niro P, Lieberman HR. Psychopharmacology (Berl). 2015;232(12):2031-2042. doi:10.1007/s00213-014-3834-5.↑

13. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers.

Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Am J Clin Nutr. 1990;51(5):759-767. doi:10.1093/ajcn/51.5.759.↑

14. The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities.

Beck TW, Housh TJ, Schmidt RJ, et al. J Strength Cond Res. 2006;20(3):506-510. doi:10.1519/18285.1.↑

15. Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis.

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17. Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis.

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18. Caffeine ingestion enhances Wingate performance: a meta-analysis.

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19. The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities.

Beck TW, Housh TJ, Schmidt RJ, et al. J Strength Cond Res. 2006;20(3):506-510. doi:10.1519/18285.1.↑

20. Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis.

Warren GL, Park ND, Maresca RD, McKibans KI, Millard-Stafford ML. Med Sci Sports Exerc. 2010;42(7):1375-1387. doi:10.1249/MSS.0b013e3181cabbd8.↑

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Polito MD, Souza DB, Casonatto J, Farinatti P. Sci Sports. 2016;31(3):119-128. doi:10.1016/J.SCISPO.2016.01.006.↑

22. The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities.

Beck TW, Housh TJ, Schmidt RJ, et al. J Strength Cond Res. 2006;20(3):506-510. doi:10.1519/18285.1.↑

23. Effect of caffeine on sport-specific endurance performance: a systematic review.

Ganio MS, Klau JF, Casa DJ, Armstrong LE, Maresh CM. J Strength Cond Res. 2009;23(1):315-324↑

24. Establishing a relationship between the effect of caffeine and duration of endurance athletic time trial events: A systematic review and meta-analysis.

Shen JG, Brooks MB, Cincotta J, Manjourides JD. J Sci Med Sport. 2019;22(2):232-238. doi:10.1016/j.jsams.2018.07.022.↑

25. The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis [published correction appears in Sports Med. 2018 Aug 9;:].

Southward K, Rutherfurd-Markwick KJ, Ali A. Sports Med. 2018;48(8):1913-1928. doi:10.1007/s40279-018-0939-8.↑

26. The effects of different doses of caffeine on endurance cycling time trial performance.

Desbrow B, Biddulph C, Devlin B, Grant GD, Anoopkumar-Dukie S, Leveritt MD. J Sports Sci. 2012;30(2):115-120. doi:10.1080/02640414.2011.632431.↑

27. Effect of caffeine on sport-specific endurance performance: a systematic review.

Ganio MS, Klau JF, Casa DJ, Armstrong LE, Maresh CM. J Strength Cond Res. 2009;23(1):315-324. doi:10.1519/JSC.0b013e31818b979a.↑

28. A review of caffeine’s effects on cognitive, physical and occupational performance.

McLellan TM, Caldwell JA, Lieberman HR. Neurosci Biobehav Rev. 2016;71:294-312. doi:10.1016/J.NEUBIOREV.2016.09.001.↑

29. International society of sports nutrition position stand: caffeine and exercise performance.

Guest NS, VanDusseldorp TA, Nelson MT, et al. J Int Soc Sports Nutr. 2021;18(1). doi:10.1186/S12970-020-00383-4.↑

30. L-Theanine reduces psychological and physiological stress responses.

Kimura K, Ozeki M, Juneja LR, Ohira H. Biol Psychol. 2007;74(1):39-45. doi:10.1016/j.biopsycho.2006.06.006.↑

31. In Search of a Safe Natural Sleep Aid.

Rao TP, Ozeki M, Juneja LR. J Am Coll Nutr. 2015;34(5):436-447. doi:10.1080/07315724.2014.926153.↑

32. Psychological effects of dietary components of tea: caffeine and L-theanine.

Bryan J. Nutr Rev. 2008;66(2):82-90. doi:10.1111/j.1753-4887.2007.00011.x.↑

33. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness.

Einöther SJ, Martens VE, Rycroft JA, De Bruin EA. Appetite. 2010;54(2):406-409. doi:10.1016/j.appet.2010.01.003.↑

34. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr.

Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. Brain Topogr. 2009;22(1):44-51.↑

35. l-Theanine and caffeine improve target-specific attention to visual stimuli by decreasing mind wandering: a human functional magnetic resonance imaging study.

Kahathuduwa CN, Dhanasekara CS, Chin SH, et al. Nutr Res. 2018;49:67-78. doi:10.1016/j.nutres.2017.11.002.↑

36. L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation.

Siamwala JH, Dias PM, Majumder S, et al. J Nutr Biochem. 2013;24(3):595-605.↑

37. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.

McGlade E, Locatelli A, Hardy J, et al. Food Nutr Sci. 2012;3(6):769-773. doi:10.4236/FNS.2012.36103.↑

38. Citicoline improves memory performance in elderly subjects.

Alvarez XA, Laredo M, Corzo D, et al. Methods Find Exp Clin Pharmacol. 1997;19(3):201-210.↑

39. The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.

McGlade E, Agoston AM, DiMuzio J, et al. J Atten Disord. 2019;23(2):121-134. doi:10.1177/1087054715593633↑

40. Citicoline improves verbal memory in aging.

Spiers PA, Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ. Arch Neurol. 1996;53(5):441-448. doi:10.1001/archneur.1996.00550050071026.↑

41. A randomized, placebo-controlled trial of citicoline add-on therapy in outpatients with bipolar disorder and cocaine dependence.

Brown ES, Gorman AR, Hynan LS. J Clin Psychopharmacol. 2007;27(5):498-502. doi:10.1097/JCP.0b013e31814db4c4.↑

42. Citicoline improves memory performance in elderly subjects.

Alvarez XA, Laredo M, Corzo D, et al. Methods Find Exp Clin Pharmacol. 1997;19(3):201-210.↑

43. An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence.

Warburton DM, Bersellini E, Sweeney E. Psychopharmacology (Berl). 2001;158(3):322-328. doi:10.1007/s002130100884.↑

44. A taurine and caffeine-containing drink stimulates cognitive performance and well-being.

Seidl R, Peyrl A, Nicham R, Hauser E. Amino Acids. 2000;19(3-4):635-642. doi:10.1007/s007260070013.↑

45. Effects and Mechanisms of Taurine as a Therapeutic Agent.

Schaffer S, Kim HW. Biomol Ther (Seoul). 2018;26(3):225-241. doi:10.4062/biomolther.2017.251.↑

46. The Effect of Taurine on the Glucose Absorption in the Small Intestine.

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48. The effect of 90 day administration of a high dose vitamin B-complex on work stress.

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49. Thiamine supplementation mood and cognitive functioning.

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52. Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time.

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Syed EU, Wasay M, Awan S. Open Neurol J. 2013;7:44-48. Published 2013 Nov 15. doi:10.2174/1874205X01307010044.↑

54. Artificial Sweeteners: History and New Concepts on Inflammation.

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55. Non-caloric artificial sweeteners and the microbiome: findings and challenges.

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56. What made Canada become a country with the highest incidence of inflammatory bowel disease: could sucralose be the culprit?

Qin X. Department of Surgery, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA. Can J Gastroenterol. 2011 Sep;25(9):511. ↑

57. Artificial Sweeteners Negatively Regulate Pathogenic Characteristics of Two Model Gut Bacteria, E. coli and E. faecalis.

Shil A, Chichger H. Int J Mol Sci. 2021;22(10):5228. Published 2021 May 15. doi:10.3390/ijms22105228.↑

58. Artificial sweeteners induce glucose intolerance by altering the gut microbiota.

Suez J, Korem T, Zeevi D, et al. Nature. 2014;514(7521):181-186. doi:10.1038/nature13793.↑

59. High-intensity sweetener consumption and gut microbiome content and predicted gene function in a cross-sectional study of adults in the United States.

Frankenfeld CL, Sikaroodi M, Lamb E, Shoemaker S, Gillevet PM. Ann Epidemiol. 2015;25(10):736-42.e4. doi:10.1016/j.annepidem.2015.06.083.↑

60. Steviol glycosides from Stevia: biosynthesis pathway review and their application in foods and medicine.

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61. Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana.

Shivanna N, Naika M, Khanum F, Kaul VK. Department of Applied Nutrition, Defence Food Research Laboratory, Mysore, India. J Diabetes Complications. 2013 Mar-Apr;27(2):103-13. ↑

62. Safety evaluation of certain food additives.

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63. Effects of Stevia rebaudiana (Bertoni) extract and N-nitro-L-arginine on renal function and ultrastructure of kidney cells in experimental type 2 Diabetes.

Ozbayer C, Kurt H, Kalender S, Ozden H, Gunes HV, Basaran A, Cakmak EA, Civi K, Kalender Y, Degirmenci I. Department of Medical Biology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey. J Med Food. 2011 Oct;14(10):1215-22. ↑

64. Toxicological significance of azo dye metabolism by human intestinal microbiota.

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66. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives.

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68. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.

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