Our "No Return Necessary"
Money-Back Guarantee

If you don’t like something of ours, guess what happens next?

No, we don’t request you deliver it to a PO box in the Gobi Desert by carrier pigeon. Nor do we ask you to fill a cursed inkwell with orc’s blood and demon saliva and then use it to complete reams of return forms written in ancient Cyrillic script.

We just . . . wait for it . . . give you your money back. Holy moo cows. And that means you can say "yes" now and decide later.

Will Vitamin B Complex supercharge your energy levels and mood?

No.

Will it instantly banish stress and boost fat burning?

Absolutely not.

But can Vitamin B Complex support your metabolism, mood, cognition, digestion, and heart health?

Yes. Or your money back.

And how can Vitamin B Complex do these things?

B vitamins are critical nutrients involved in the production of numerous enzymes and hormones in the body that regulate processes like cell growth and repair, brain and nervous system function, red blood cell production, protein, fat, and carbohydrate metabolism, and more.[8][9][10][11][12][13][14][15]

Despite their importance, however, research shows that as many as 97% of people consume inadequate levels of one or more B vitamins for optimal health and performance.[16]

These “subclinical deficiencies” are serious, too—they’re associated with numerous health and performance problems, including mood disruption, impaired muscle function and recovery, fatigue, and more.[17][18][19][20][21]

Now, while it’s possible to get enough B vitamins to maintain health through diet alone, this can be difficult because . . .

  1. It requires eating several servings per day of foods that many people don’t eat regularly, including liver, seafood, eggs, dairy, legumes, leafy greens, and seeds.
  2. Fruit, vegetables, and grains often contain fewer B vitamins than they did in the past.[22][23]
  3. Processing and cooking can reduce the vitamin B content of foods by as much as 90%.[24][25][26]

Additionally, research suggests that the recommended daily allowance (RDA) for B vitamins is adequate for preventing deficiencies, but may not produce optimal health, longevity, and performance, which should be the ultimate goal.[27][28][29][30] This is particularly true for vegetarians and vegans, who often struggle to meet their body’s vitamin B needs through diet alone.[31][32]

There’s also reason to believe that people who are physically active have a greater need for B vitamins than sedentary folks, which can put them at an increased risk of developing an insufficiency.[33][34][35][36]

Thus, many health-conscious people who eat a nutritious diet also choose to supplement with B vitamins, especially if they’re physically active.

So order now. Try Vitamin B Complex risk-free, and see for yourself why we believe it’s the perfect vitamin B supplement.

Will Vitamin B Complex supercharge your energy levels and mood?

No.

Will it instantly banish stress and boost fat burning?

Absolutely not.

But can Vitamin B Complex support your metabolism, mood, cognition, digestion, and heart health?

Yes. Or your money back.

And how can Vitamin B Complex do these things?

B vitamins are critical nutrients involved in the production of numerous enzymes and hormones in the body that regulate processes like cell growth and repair, brain and nervous system function, red blood cell production, protein, fat, and carbohydrate metabolism, and more.[1][2][3][4][5][6][7][8]

Despite their importance, however, research shows that as many as 97% of people consume inadequate levels of one or more B vitamins for optimal health and performance.[9]

These “subclinical deficiencies” are serious, too—they’re associated with numerous health and performance problems, including mood disruption, impaired muscle function and recovery, fatigue, and more.[10][11][12][13][14]

Now, while it’s possible to get enough B vitamins to maintain health through diet alone, this can be difficult because . . .

  1. It requires eating several servings per day of foods that many people don’t eat regularly, including liver, seafood, eggs, dairy, legumes, leafy greens, and seeds.
  2. Fruit, vegetables, and grains often contain fewer B vitamins than they did in the past.[15][16]
  3. Processing and cooking can reduce the vitamin B content of foods by as much as 90%.[17][18][19]

Additionally, research suggests that the recommended daily allowance (RDA) for B vitamins is adequate for preventing deficiencies, but may not produce optimal health, longevity, and performance, which should be the ultimate goal.[20][21][22][23] This is particularly true for vegetarians and vegans, who often struggle to meet their body’s vitamin B needs through diet alone.[24][25]

There’s also reason to believe that people who are physically active have a greater need for B vitamins than sedentary folks, which can put them at an increased risk of developing an insufficiency.[26][27][28][29]

Thus, many health-conscious people who eat a nutritious diet also choose to supplement with B vitamins, especially if they’re physically active.

Our Vitamin B Complex stands out because:

  • 97 peer-reviewed scientific studies support our Vitamin B Complex’s doses of B vitamins, choline, coenzyme Q10, and inositol[33] That’s 1,058 pages of scientific research that shows Vitamin B Complex works the way we say it does.
  • Contains no artificial fillers, food dyes, or other chemical junk[31] While these types of chemicals may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health. And that’s why you won’t find them in Vitamin B Complex.
  • Analyzed for purity and potency in a state-of-the-art ISO 17025 accredited lab[32] Every bottle of Vitamin B Complex is guaranteed to provide exactly what the label claims and nothing else—no heavy metals, microbes, allergens, or other contaminants.
  • Total formulation transparency (no proprietary blends)[33] This means you know exactly what’s in every serving of Vitamin B Complex—every dose of every ingredient—and can verify the accuracy and efficacy of the formulation.
  • Made in the USA in NSF-certified and FDA-inspected and cGMP-compliant facilities

Vitamin B Complex is also backed by our “No Return Necessary” money-back guarantee that works like this:

If you don’t absolutely love Vitamin B Complex, just let us know, and we’ll give you a full refund on the spot. No forms or return necessary.

So order now. Try Vitamin B Complex risk-free, and see for yourself why we believe it’s the perfect vitamin B supplement.

Notice to California Consumers

WARNING: Consuming this product can expose you to chemicals including lead which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

Legion Vitamin B Complex Ingredients (685.6 milligrams per serving)

8 Essential Vitamin B Vitamins (85.6 milligrams per serving)

Vitamin B Complex contains clinically effective doses of all eight essential B vitamins that are vital for many aspects of health, performance, and wellbeing, including metabolism; brain, nervous, and DNA health and function; cellular growth and repair; hormone production, and more.[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91]

Choline (250 milligrams per serving)

Choline is an essential nutrient that was formerly considered a B vitamin (B4) but now is recognized as a distinct substance. It’s found in foods like meat, fish, nuts, beans, vegetables, and eggs, and it’s vital for brain, nervous, and liver health and function.

Research shows that supplementation with choline . . .

While it’s possible to get enough choline through your diet to support optimal health, it can be difficult because it requires eating adequate amounts of foods that many people don’t eat, including eggs, liver, and peanuts.

This is why research shows that up to 94% of women and 89% of men in America don’t consume the minimum amount of choline needed to support health.[96]

There is no recommended daily allowance for choline, but the U.S. Food and Nutrition Board has set an Adequate Intake (AI) level of 550 milligrams per day for adult men and 425 milligrams per day for women.

Inositol (250 milligrams per serving)

Inositol, also (now erroneously) known as vitamin B8, is a group of molecules involved in cellular signaling and the health and function of cell membranes.

While it’s possible to get enough inositol through your diet to support optimal health, it can be difficult because it requires eating adequate amounts of foods that many people don’t eat, including citrus fruits, whole grains, beans, nuts, and green leafy vegetables.

Research shows that supplementation with inositol . . .

There is no recommended daily allowance for inositol, but it’s often suggested that adult men and women consume approximately 1-to-4 grams per day to support health.

Coenzyme Q10 (100 milligrams per serving)

Coenzyme Q10 (CoQ10) is a substance that helps enzymes perform bodily processes (hence “coenzyme”). It’s found in a variety of foods, especially organ meats such as heart, liver, and kidney.

It’s present in every cell of the body, particularly in the mitochondria (the “powerhouses” of the cells), and it plays a crucial role in the production of cellular energy and functions as an antioxidant.

Moreover, as cellular CoQ10 levels decline with age, scientists believe that this circumstance may contribute to the development of age-related disorders, including the aging process itself.[100][101][102][103]

Research shows that supplementation with CoQ10 . . .

  • Reduces oxidative stress[104]
  • Enhances antioxidant protection[105]
  • Supports healthy inflammation levels[106]
  • Boosts physical performance and recovery[107][108][109]
  • Improves male fertility[110]

The clinically effective dose of CoQ10 is 50-to-200 milligrams.

No Artificial Food Dyes, Fillers, or Other Unnecessary Junk

Artificial food dyes aren’t a hazard per se, but studies show they can cause negative effects in some people, including gastrointestinal toxicity and behavioral disorders.[111][112][113][114][115]

No Artificial Food Dyes or Other Chemical Junk

Third-Party Lab Tested for Potency & Purity

Every bottle of Vitamin B Complex is analyzed in a state-of-the-art ISO 17025 accredited lab to verify what is and isn’t in it. That way, you know exactly what you’re getting and putting into your body.

Third-Party Lab Tested for Potency & Purity

See how Legion Vitamin B Complex compares to the rest.

  • Active Ingredients
    Per Serving
  • Clinically Effective Ingredients
    & Doses
  • B Vitamin Complex
  • Choline
  • Inositol
  • Coenzyme Q10
  • Third-Party Lab Tested
  • Labdoor Certified Brand
  • Price Per Serving
  • Legion
    Vitamin B Complex

    Vitamin B Complex
  • 685.6 mg
    per serving
  • True
  • 85.6 mg
    per serving
  • 250 mg
    per serving
  • 250 mg
    per serving
  • 250 mg
    per serving
  • True
  • True
  • $
  • NOW Foods
    Co-Enzyme B-Complex

    NOW Vitamin B
  • 551.9 mg
    per serving
  • False
  • 301.9 mg
    per serving
  • 25 mg
    per serving
  • 30 mg
    per serving
  • 10 mg
    per serving
  • Question Mark
  • False
  • $0.43
  • Thorne
    Basic B-Complex

    Thorne Vitamin B
  • 409.4 mg
    per serving
  • True
  • 381.4 mg
    per serving
  • 28 mg
    per serving
  • False
  • False
  • Question Mark
  • False
  • $0.43
  • Nature Made
    B-100 Complex

    Nature Made Vitamin B
  • 556.8 mg
    per serving
  • True
  • 500.8 mg
    per serving
  • False
  • False
  • False
  • Question Mark
  • False
  • $0.35

The #1 brand of all-natural sports supplements.

Over 5+ million bottles sold to over 1+ million customers who have left us over 45,000 5-star reviews.

Natural Ingredients
Natural Ingredients

Vitamin B Complex doesn’t just “contain natural ingredients”—every ingredient is naturally sourced. We don’t use artificial or synthetic substances of any kind.

Science-Backed Ingredients
Science-Backed Ingredients

Every ingredient in Vitamin B Complex is backed by peer-reviewed scientific research demonstrating clear benefits in healthy humans.

Clinically Effective Doses
Clinically Effective Ingredients & Doses

Every ingredient in Vitamin B Complex is included at clinically effective levels, which are the exact amounts shown to be safe and effective in peer-reviewed scientific research.

Lab Tested
Third-Party Lab Tested

Vitamin B Complex is tested by third-party labs for heavy metals, microbes, allergens, and other contaminants to ensure it meets FDA purity standards.

Made in USA
Made in the USA

Vitamin B Complex is made in America with globally sourced ingredients in NSF-certified, FDA-inspected facilities that adhere to Current Good Manufacturing Practice (cGMP) standards.

100% Money-Back-Guarantee
"No Return Necessary"
Money-Back Guarantee

If you don't absolutely love Vitamin B Complex, you get a prompt and courteous refund. No forms or returns necessary.

Trusted by scientists, doctors, and everyday fitness folk alike.

Previous
  • Sal Di Stefano, Justin Andrews, and Adam Schafer

    "When it comes to quality and integrity, Legion is among the best. Their products only include ingredients that are backed by research and in doses that are proven to be effective in scientific studies."

    Sal Di Stefano, Justin Andrews, and Adam Schafer

    Hosts of The Mind Pump Podcast
  • Dr. Bill Campbell, PhD

    "Legion is science-based at its core. Not only do they dose all of their products based on the clinical doses proven to be effective by scientific studies, they go above and beyond the their competitors by funding new research."

    Dr. Bill Campbell, PhD

    Professor of Exercise Science at University of South Florida
  • Jordan Syatt

    "Legion is a tremendous company run by people I trust and respect. The quality of their supplements is second to no one. And while I don’t use many supplements, the only ones I do come from Legion."

    Jordan Syatt

    Strength and Nutrition Coach
  • Dr. Spencer Nadolsky, MD

    "There are a lot of sleazy supplement companies out there, but Legion is not one of them. Their products are free of fillers and inactive ingredients and they take the time (and money) to test them with independent labs to ensure you're getting what you pay for."

    Dr. Spencer Nadolsky, MD

    Board-Certified Family Medicine Physician and a Diplomate of the American Board of Obesity Medicine
  • Menno Henselmans, MS

    "Legion consults with nutrition experts to make honest, science-based products and then proves they're genuine with independent lab work. That's how all supplement companies should operate."

    Menno Henselmans, MS

    Founder of Bayesian Bodybuilding, Published Scientist, and Physique Coach
  • Kurtis Frank

    "With Legion, you really do get what you pay for. Each and every product is packed with effective doses of effective ingredients, and what’s on the label is what's actually in the bottle."

    Kurtis Frank

    Co-Founder and Former Lead Researcher & Writer of Examine.com
  • James Krieger, MS

    "There are three reasons I like Legion. First, they use ingredients backed by independent, peer-reviewed scientific studies. Second, the quality of their supplements exceeds many in the industry and you know you’re getting what’s on the label. Third, Mike Matthews is a solid evidence-based guy who doesn’t over-hype."

    James Krieger, MS

    Published Scientist, Author, and Speaker
  • Chris Barakat, MS

    "Legion is the only company doing everything right. They make effective products that are backed by scientific evidence, properly dose all of their ingredients, source every ingredient from the highest-quality sources, and are transparent about exactly what goes in each and every product."

    Chris Barakat, MS

    Published Scientist and Physique Coach
Next
Vitamin B Complex Lab Test

Frequently Asked Questions

How do I use Vitamin B Complex?
What makes Vitamin B Complex different from other vitamin B complex supplements on the market?
Can I take Vitamin B Complex with other Legion supplements?
A supplement I take already contains B vitamins. Can I benefit from Vitamin B Complex?
How much of the different B vitamins should I take per day? How much is too much?
What type of effects should I notice?
What does the Prop65 warning on the labels mean?
Can Vitamin B Complex be taken while pregnant or breastfeeding?
Can Vitamin B Complex be taken with medication?
Is Vitamin B Complex gluten-free? Soy-free? Dairy-free?
Is Vitamin B Complex vegetarian or vegan friendly?

+References

8. Office of Dietary Supplements - Biotin.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

9. Office of Dietary Supplements - Vitamin B12.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

10. Office of Dietary Supplements - Folate.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

11. Office of Dietary Supplements - Pantothenic Acid.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

12. Office of Dietary Supplements - Vitamin B6.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

13. Office of Dietary Supplements - Niacin.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

14. Office of Dietary Supplements - Riboflavin.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

15. Office of Dietary Supplements - Thiamin.

National Institutes of Health Office of Dietary Supplements. Accessed October 16, 2023.

16. What We Eat in America: Usual Nutrient Intake from Food, Beverages, and Dietary Supplements.

United States Department of Agriculture. Accessed May 10, 2023.

17. Thiamin, riboflavin and vitamin B6: impact of restricted intake on physical performance in man.

Beek EJV Der, Dokkum W Van, Wedel M, Schrijver J, Berg H Van Den. J Am Coll Nutr. 1994;13(6):629-640. doi:10.1080/07315724.1994.10718459.

18. Potential mental and physical benefits of supplementation with a high-dose, B-complex multivitamin/mineral supplement: What is the evidence?

Sarris J, Mehta B, Óvári V, Giménez IF. Nutr Hosp. 2021;38(6):1277-1286. doi:10.20960/NH.03631.

19. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial.

Carroll D, Ring C, Suter M, Willemsen G. Psychopharmacology (Berl). 2000;150(2):220-225. doi:10.1007/S002130000406.

20. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.

Kennedy DO, Veasey R, Watson A, et al. Psychopharmacology (Berl). 2010;211(1):55-68. doi:10.1007/S00213-010-1870-3.

22. Historical changes in the mineral content of fruit and vegetables in the UK from 1940 to 2019: a concern for human nutrition and agriculture.

Mayer AMB, Trenchard L, Rayns F. Int J Food Sci Nutr. 2022;73(3):315-326. doi:10.1080/09637486.2021.1981831.

23. Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999.

Davis DR, Epp MD, Riordan HD, Davis DR. J Am Coll Nutr. 2004;23(6):669-682. doi:10.1080/07315724.2004.10719409.

24. Cooking losses of thiamin in food and its nutritional significance.

Kimura M, Itokawa Y, Fujiwara M. J Nutr Sci Vitaminol (Tokyo). 1990;36 Suppl 1:S17-S24. doi:10.3177/JNSV.36.4-SUPPLEMENTI_S17.

25. The effect of cooking on the vitamin B6 content of foods.

Elmadfa, I., & Majchrzak, D. (1999). International Journal of Vitamin and Nutrition Research, 69(3), 184-187

26. A carotenoids in biofortified staple crops.

La Frano MR, de Moura FF, Boy E, Lönnerdal B, Burri BJ. Bioavailability of iron, zinc, and provitamin Nutr Rev. 2014;72(5):289-307. doi:10.1111/NURE.12108.

27. Potential mental and physical benefits of supplementation with a high-dose, B-complex multivitamin/mineral supplement: What is the evidence?

Sarris J, Mehta B, Óvári V, Giménez IF. Nutr Hosp. 2021;38(6):1277-1286. doi:10.20960/NH.03631.

28. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial.

Carroll D, Ring C, Suter M, Willemsen G. Psychopharmacology (Berl). 2000;150(2):220-225. doi:10.1007/S002130000406.

29. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.

Kennedy DO, Veasey R, Watson A, et al. Psychopharmacology (Berl). 2010;211(1):55-68. doi:10.1007/S00213-010-1870-3.

31. Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians and vegans: results from a cross-sectional analysis of the EPIC-Oxford cohort study.

Gilsing AMJ, Crowe FL, Lloyd-Wright Z, et al. Eur J Clin Nutr. 2010;64(9):933-939. doi:10.1038/EJCN.2010.142.

32. Vegan diets: practical advice for athletes and exercisers.

Rogerson D. J Int Soc Sports Nutr. 2017;14(1). doi:10.1186/S12970-017-0192-9.

33. B-vitamins and exercise: does exercise alter requirements?

Woolf K, Manore MM. Int J Sport Nutr Exerc Metab. 2006;16(5):453-484. doi:10.1123/IJSNEM.16.5.453.

34. Vegan diets: practical advice for athletes and exercisers.

Rogerson D. J Int Soc Sports Nutr. 2017;14(1). doi:10.1186/S12970-017-0192-9.

35. Vitamin and mineral status: Effects on physical performance.

Lukaski HC. Nutrition. 2004;20(7-8):632-644. doi:10.1016/j.nut.2004.04.001.

36. ISSN exercise & sports nutrition review update: research & recommendations.

Kerksick CM, Wilborn CD, Roberts MD, et al. J Int Soc Sport Nutr 2018 151. 2018;15(1):1-57. doi:10.1186/S12970-018-0242-Y.

30.

That’s 1,411 pages of scientific research that shows Vitamin B Complex works exactly like we say it does.

31.

While these types of chemicals may not be as dangerous as some people claim, studies suggest that regular consumption of them may indeed be harmful to our health. And that’s why you won’t find them in Vitamin B Complex.

32.

Every bottle of Vitamin B Complex is guaranteed to provide exactly what the label claims and nothing else—no heavy metals, microbes, allergens, or other contaminants.

33.

This means you know exactly what’s in every serving of Vitamin B Complex—every dose of every ingredient—and can verify the accuracy and efficacy of the formulation.

37. Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption.

Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. Am J Med. 1991;91(2):151-155. doi:10.1016/0002-9343(91)90007-K.

38. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy.

Shimon H, Almog S, Vered Z, et al. Am J Med. 1995;98(5):485-490. doi:10.1016/S0002-9343(99)80349-0.

39. Clinical manifestations of thiamine deficiency.

Mimenza Alvarado A, Aguilar Salinas B. Acta Neurol Mex. 2009 Dec;24(4):355-63.

40. Abnormal thiamine-dependent processes in Alzheimer’s Disease. Lessons from diabetes.

Gibson GE, Hirsch JA, Cirio RT, Jordan BD, Fonzetti P, Elder J. Mol Cell Neurosci. 2013;55:17-25. doi:10.1016/J.MCN.2012.09.001.

41. A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives.

Lonsdale D. Evid Based Complement Alternat Med. 2006;3(1):49-59. doi:10.1093/ECAM/NEK009.

42. Thiamin function, metabolism, uptake, and transport.

Manzetti S, Zhang J, Van Der Spoel D. Biochemistry. 2014;53(5):821-835. doi:10.1021/BI401618Y.

43. Use of vitamin supplements and cataract: The Blue Mountains eye Study.

Kuzniarz M, Mitchell P, Cumming RG, Flood VM. Am J Ophthalmol. 2001;132(1):19-26. doi:10.1016/S0002-9394(01)00922-9.

44. Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.

Michels AJ, Hagen TM, Frei B. Annu Rev Nutr. 2013;33:45-70. doi:10.1146/ANNUREV-NUTR-071812-161246.

45. Prophylaxis of migraine headaches with riboflavin: A systematic review.

Thompson DF, Saluja HS. J Clin Pharm Ther. 2017;42(4):394-403. doi:10.1111/JCPT.12548.

46. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre.

Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G. Eur J Neurol. 2004;11(7):475-477. doi:10.1111/J.1468-1331.2004.00813.X.

47. Riboflavin and health: A review of recent human research.

Thakur K, Tomar SK, Singh AK, Mandal S, Arora S. Crit Rev Food Sci Nutr. 2017;57(17):3650-3660. doi:10.1080/10408398.2016.1145104.

48. Riboflavin (vitamin B-2) and health.

Powers HJ. Am J Clin Nutr. 2003;77(6):1352-1360. doi:10.1093/AJCN/77.6.1352.

49. Influence of nicotinic acid on serum cholesterol in man.

Altschul R, Hoffer A, Stephen JD. Arch Biochem Biophys. 1955;54(2):558-559. doi:10.1016/0003-9861(55)90070-9.

50. The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression.

Lavigne PM, Karas RH. J Am Coll Cardiol. 2013;61(4):440-446. doi:10.1016/J.JACC.2012.10.030.

51. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin.

PL C, KG B, NK W, et al. J Am Coll Cardiol. 1986;8(6):1245-1255. doi:10.1016/S0735-1097(86)80293-5.

52. Mechanism of action of niacin.

Kamanna VS, Kashyap ML. Am J Cardiol. 2008;101(8A). doi:10.1016/J.AMJCARD.2008.02.029.

53. Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline.

Morris MC, Evans DA, Bienias JL, et al. J Neurol Neurosurg Psychiatry. 2004;75(8):1093-1099. doi:10.1136/JNNP.2003.025858.

54. Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer’s disease.

Foster PP, Rosenblatt KP, Kuljiš RO. Front Neurol. 2011;2. doi:10.3389/FNEUR.2011.00028.

55. Nicotinic acid/niacinamide and the skin.

W G. J Cosmet Dermatol. 2004;3(2):88-93. doi:10.1111/J.1473-2130.2004.00115.X.

56. Niacinamide: A B vitamin that improves aging facial skin appearance.

Bissett DL, Oblong JE, Berge CA. Dermatol Surg. 2005;31(7 Pt 2):860-866. doi:10.1111/J.1524-4725.2005.31732.

57. Niacin status, NAD distribution and ADP-ribose metabolism.

Kirkland J. Curr Pharm Des. 2009;15(1):3-11. doi:10.2174/138161209787185823.

58. Niacin requirements for genomic stability.

Kirkland JB. Mutat Res. 2012;733(1-2):14-20. doi:10.1016/J.MRFMMM.2011.11.008.

59. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids.

Wu BJ, Yan L, Charlton F, Witting P, Barter PJ, Rye KA. Arterioscler Thromb Vasc Biol. 2010;30(5):968-975. doi:10.1161/ATVBAHA.109.201129.

60. Pharmacodynamic Basis of Herbal Medicine.

Ebadi M. September 2006. doi:10.1201/9781420006452.

61. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm.

Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Ann N Y Acad Sci. 2002;957:239-249. doi:10.1111/J.1749-6632.2002.TB02920.X.

62. Hyperlipoproteinemia, diabetes and alcohol consumption: effectiveness of treatment with pantethine.

Gaddi A, Descovich GC, Noseda G, et al. Acta Biomed Ateneo Parmense. 1982;53(3-4):137-52.

65. Nutritional factors and hair loss.

Rushton DH. Clin Exp Dermatol. 2002;27(5):396-404. doi:10.1046/J.1365-2230.2002.01076.X.

66. Relevance of vitamins C and E in cutaneous photoprotection.

B E-K, J R. J Cosmet Dermatol. 2005;4(1):4-9. doi:10.1111/J.1473-2165.2005.00151.X.

67. A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne.

Yang M, Moclair B, Hatcher V, et al. Dermatol Ther (Heidelb). 2014;4(1):93-101. doi:10.1007/S13555-014-0052-3.

68. Vitamin B6: a long known compound of surprising complexity.

Mooney S, Leuendorf JE, Hendrickson C, Hellmann H. Molecules. 2009;14(1):329-351. doi:10.3390/MOLECULES14010329.

69. Vitamin B-6: a status report.

Leklem JE. J Nutr. 1990;120 Suppl 11(4):1503-1507. doi:10.1093/JN/120.SUPPL_11.1503.

71. The effect of vitamin B6 on cognition.

Malouf R, Grimley Evans J. Cochrane database Syst Rev. 2003;(4). doi:10.1002/14651858.CD004393.

72. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review.

Kennedy DO. Nutrients. 2016;8(2):68. doi:10.3390/NU8020068.

73. Vitamin B6 and immune competence.

Rail LC, Meydani SN. Nutr Rev. 1993;51(8):217-225. doi:10.1111/J.1753-4887.1993.TB03109.X.

74. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment.

Tamura J, Kubota K, Murakami H, et al. Clin Exp Immunol. 1999;116(1):28-32. doi:10.1046/J.1365-2249.1999.00870.X.

75. Vitamins and minerals: their role in nail health and disease.

Scheinfeld N, Dahdah MJ, Scher R. J Drugs Dermatol. 2007;6(8):782-787.

76. Serum Biotin Levels in Women Complaining of Hair Loss.

Trüeb RM. Int J Trichology. 2016;8(2):73-77. doi:10.4103/0974-7753.188040.

77. Present Knowledge in Nutrition.

Zempleni J, Wijeratne SSK, Kuroishi T. Biotin. In: Erdman JW, Macdonald IA, Zeisel SH, eds. 10th ed. Washington, DC: Wiley-Blackwell; 2012:359-74.

78. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study.

MRC Vitamin Study Research Group. Lancet. 1991;338(8760):131-137.

79. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation.

Czeizel AE, Dudás I. N Engl J Med. 1992;327(26):1832-1835. doi:10.1056/NEJM199212243272602.

80. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes.

Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. JAMA. 1995;274(13):1049-1057. doi:10.1001/jama.1995.03530130055028.

81. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.

Wald DS, Law M, Morris JK. BMJ. 2002;325(7374):1202. doi:10.1136/bmj.325.7374.1202.

82. Treatment of depression: time to consider folic acid and vitamin B12.

Coppen A, Bolander-Gouaille C. J Psychopharmacol. 2005;19(1):59-65. doi:10.1177/0269881105048899.

83. Folate, vitamin B12, and neuropsychiatric disorders.

Bottiglieri T. Nutr Rev. 1996;54(12):382-390. doi:10.1111/j.1753-4887.1996.tb03851.x.

84. Low vitamin B-12 status and risk of cognitive decline in older adults.

Clarke R, Birks J, Nexo E, et al. Am J Clin Nutr. 2007;86(5):1384-1391. doi:10.1093/ajcn/86.5.1384.

85. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination.

Tangney CC, Aggarwal NT, Li H, et al. [published correction appears in Neurology. 2011 Nov 8;77(19):1773]. Neurology. 2011;77(13):1276-1282. doi:10.1212/WNL.0b013e3182315a33.

86. Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study.

Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. Eur J Clin Nutr. 2000;54(5):424-428. doi:10.1038/sj.ejcn.1600991.

87. Oxygen, oxidants, and antioxidants in wound healing: an emerging paradigm.

Sen CK, Khanna S, Gordillo G, Bagchi D, Bagchi M, Roy S. Ann N Y Acad Sci. 2002;957:239-249. doi:10.1111/J.1749-6632.2002.TB02920.X.

88. Hyperlipoproteinemia, diabetes and alcohol consumption: effectiveness of treatment with pantethine.

Gaddi A, Descovich GC, Noseda G, et al. Acta Biomed Ateneo Parmense. 1982;53(3-4):137-52.

91. Nutritional factors and hair loss.

Rushton DH. Clin Exp Dermatol. 2002;27(5):396-404. doi:10.1046/J.1365-2230.2002.01076.X.

85. Vitamin B12 (cobalamin) deficiency in elderly patients.

CMAJ. 2004;171(3):251-259. doi:10.1503/cmaj.1031155

Andrès E, Loukili NH, Noel E, et al.

86. Oh R, Brown DL. Vitamin B12 deficiency.

Am Fam Physician. 2003;67(5):979-986.

87. Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study.

Tucker KL, Hannan MT, Qiao N, et al. J Bone Miner Res. 2005;20(1):152-158. doi:10.1359/JBMR.041018.

92. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study.

Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. JAMA. 1995;274(11):902-907.

93. Choline metabolism as a basis for the selective vulnerability of cholinergic neurons.

Wurtman RJ. Trends Neurosci. 1992;15(4):117-122. doi:10.1016/0166-2236(92)90351-8.

94. Phosphatidylcholine and choline homeostasis.

Li Z, Vance DE. J Lipid Res. 2008;49(6):1187-1194. doi:10.1194/jlr.R700019-JLR200.

95. Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction.

Resseguie ME, da Costa KA, Galanko JA, Patel M, Davis IJ, Zeisel SH. J Biol Chem. 2011;286(2):1649-1658. doi:10.1074/jbc.M110.106922.

96. What We Eat in America: Usual Nutrient Intake from Food and Beverages.

United States Department of Agriculture.

97. Double-blind, controlled trial of inositol treatment of depression.

Levine J, Barak Y, Gonzalves M, et al. Am J Psychiatry. 1995;152(5):792-794. doi:10.1176/AJP.152.5.792.

98. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.

Benjamin J, Levine J, Fux M, Aviv A, Levy D, Belmaker RH. Am J Psychiatry. 1995;152(7):1084-1086. doi:10.1176/AJP.152.7.1084.

99. Brain-Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism Differentially Predicts Hippocampal Function in Medication-Free Patients with Schizophrenia.

Eisenberg DP, Ianni AM, Wei SM, et al. Mol Psychiatry. 2013;18(6):713. doi:10.1038/MP.2012.187.

100. Coenzyme Q10 Levels Associated With Cognitive Functioning and Executive Function in Older Adults.

Fernández-Portero C, Amián JG, Bella R, López-Lluch G, Alarcón D. J Gerontol A Biol Sci Med Sci. 2023;78(1):1-8. doi:10.1093/gerona/glac152.

101. Levels of Plasma Coenzyme Q10 Are Associated with Physical Capacity and Cardiovascular Risk in the Elderly.

de la Bella-Garzón R, Fernández-Portero C, Alarcón D, Amián JG, López-Lluch G. Antioxidants (Basel). 2022;11(2):279. Published 2022 Jan 29. doi:10.3390/antiox11020279.

102. Disorders of Human Coenzyme Q10 Metabolism: An Overview. Int J Mol Sci. 2020;21(18):6695.

Hargreaves I, Heaton RA, Mantle D. Published 2020 Sep 13. doi:10.3390/ijms21186695.

103. Coenzyme Q10: From bench to clinic in aging diseases, a translational review. Crit Rev Food Sci Nutr.

Gutierrez-Mariscal FM, Yubero-Serrano EM, Villalba JM, Lopez-Miranda J. 2019;59(14):2240-2257. doi:10.1080/10408398.2018.1442316.

104. The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials.

Sangsefidi ZS, Yaghoubi F, Hajiahmadi S, Hosseinzadeh M. Food Sci Nutr. 2020;8(4):1766-1776. Published 2020 Mar 19. doi:10.1002/fsn3.1492.

107. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men.

Gökbel H, Gül I, Belviranl M, Okudan N. J Strength Cond Res. 2010;24(1):97-102. doi:10.1519/JSC.0b013e3181a61a50.

108. Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10.

Gül I, Gökbel H, Belviranli M, Okudan N, Büyükbaş S, Başarali K. J Sports Med Phys Fitness. 2011;51(2):305-312.

109. Effects of coenzyme Q10 supplementation on liver mitochondrial function and aerobic capacity in adolescent athletes.

Liao P, Zhang Y, Liao Y, Zheng NJ, Zhang X. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23(4):491-494.

110. Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation.

Talevi R, Barbato V, Fiorentino I, Braun S, Longobardi S, Gualtieri R. Reprod Biol Endocrinol. 2013;11:81. Published 2013 Aug 16. doi:10.1186/1477-7827-11-81.

111. Toxicological significance of azo dye metabolism by human intestinal microbiota.

Feng J, Cerniglia CE, Chen H. Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, AR , USA. Front Biosci (Elite Ed). 2012 Jan 1;4:568-86.

112. Artificial food dyes and attention deficit hyperactivity disorder.

Kanarek RB. Department of Psychology, Tufts University, Medford, Massachusetts, USA. Nutr Rev. 2011 Jul;69(7):385-91.

113. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives.

Nigg JT, Lewis K, Edinger T, Falk M. Oregon Health and Science University, Portland, OR, USA. J Am Acad Child Adolesc Psychiatry. 2012 Jan;51(1):86-97.e8.

114. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial.

McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO, Stevenson J. School of Psychology, Department of Child Health, University of Southampton, Southampton, UK. Lancet. 2007 Nov 3;370(9598):1560-7.

115. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.

Gao Y, Li C, Shen J, Yin H, An X, Jin H. Scientific and Technological College of Chemistry and Biology, Yantai Univ., Yantai, PR China. J Food Sci. 2011 Aug;76(6):T125-9.