Ascend | Nootropic
IT’S-ON-US MONEY-BACK GUARANTEE
Many companies offer a money-back guarantee because they know the majority of dissatisfied customers aren’t going to go through the hassle of actually returning the product to get their money back. We don’t play these games because we don’t have to, the quality of our products makes it unnecessary.
If you order any of our supplements for the first time and don’t like it, you can keep it. Just notify us and we’ll give you a full refund on the spot. No complicated forms and no return necessary.
To protect ourselves from fraud, the It’s-On-Us guarantee is only valid for first time purchases of a product, and redeemable up to three months after purchase. If you bought more than one bottle of a supplement on your first purchase and don’t like it, we would ask that you send the unopened bottles back to us for a refund because we can put them back into our sellable inventory.
Many nootropics use chemicals to alter your neurochemistry and produce immediate, noticeable benefits, but also undermine critical brain functions and result in unwanted side effects.
ASCEND is different.
Instead of targeting just one aspect of your mental capabilities at the expense of others or temporarily supercharging your nervous system, ASCEND helps create a better environment for your brain chemistry to work in by enhancing the development, function, complexity, and resilience of your body’s billions of neurons.
So, if you want a healthier, happier, and higher-performing brain that allows you to think faster, focus deeper, and feel better, then you want to try ASCEND today.Learn More
How well you can focus, think, and remember will determine, to a large degree, how much joy and satisfaction you get from life.
These abilities will determine how well you can learn new things and acquire new skills, how efficiently and productively you can work, how well you can communicate and connect with others, and how you generally perceive and understand yourself and the world around you.
They don’t necessarily come easy, either.
Thanks to technology, we’re almost always within arms reach of an overwhelming amount of information and an endless number of distractions, and research shows that the more we give in to our desires for diversion, the harder it becomes to intentionally concentrate and process information. 
Other lifestyle factors undermine our natural cognitive abilities as well. Too many people eat too much “unhealthy” food, don’t exercise or sleep enough, and mismanage stress, and as a result, struggle to control and direct their attention and thoughts.
Thus, the first things anyone looking to improve their mental capabilities should do are spend less time glued to technology chasing instant gratification, eat a diet rich in nutritious, relatively unprocessed foods, exercise regularly, and get enough sleep.
That’s not all you can do, though, and that’s why we created ASCEND.
In short, ASCEND is a nootropic (“brain booster”) that supports and enhances your focus, memory, mental speed, creativity, and mood, as well as your overall brain health.
Unlike many nootropics, ASCEND doesn’t target just one aspect of your mental capabilities at the expense of others or rely on stimulants to produce immediately noticeable effects that may also undermine critical functions or result in unwanted side effects.
Instead, ASCEND’s formulation provides your brain with key building blocks, much like amino acids are to muscle tissue, and by increasing the availability of these substances, you not only improve how your brain operates, but also how it repairs and reconstructs itself.
This means that ASCEND does more than just sharpen your focus and mind and elevate your mood, it also helps your body build a healthier, happier, and higher-performing brain. In this way, ASCEND can also enhance the effects of other nootropics that you may want to “stack” it with.
Let’s take a look at the formulation.
Alpha-Glycerophosphocholine (Alpha-GPC) is a compound that increases the activity of acetylcholine in the brain, which is a chemical used by nerves to communicate with each other (neurotransmitter).
Alpha-GPC is a rather unique molecule for several reasons:
- It isn’t gobbled up by the choline-loving liver and thus can reach the brain and act on it directly.
- It helps your body maintain sufficient levels of acetylcholine, which in turn supports optimal physical and mental performance.
- It provides your body with glycerophosphate, which is a substance in the membranes of nerve cells that supports brain health and function.
All this is why research shows that supplementation with Alpha-GPC can...
THE CLINICALLY EFFECTIVE DOSAGE OF ALPHA-GPC IS BETWEEN 150 AND 1,200 MILLIGRAMS, AND IT APPEARS THAT FOR THE PURPOSES OF INCREASING COGNITION, 150 MILLIGRAMS PRODUCES SIMILAR EFFECTS AS 500 MILLIGRAMS. 
Cytidine Diphosphate-Choline (CDP-Choline) is another compound that can reach the brain and provide it with choline—an essential nutrient for brain development and health—as well as a precursor to another vital nutrient, uridine.
Research shows that supplementation with CDP-Choline can…
- Improve memory (and verbal memory in particular). 
- Mitigate cognitive decline as we age. 
- Improve focus. 
The clinically effective dosage of CDP-Choline is between 250 to 500 milligrams for focus and 500 to 1,000 milligrams for preventing cognitive decline, and ASCEND contains 300 milligrams.
We chose this dosage for two reasons:
- It gets us to 600 milligrams of active acetylcholine-enhancing agents (Alpha-GPC being the other).
- The attentional performance enhancement is seen at lower dosages (250 milligrams has outperformed 500 milligrams). 
CDP-Choline provides us with a fair amount of uridine but not enough for our liking, so we’ve included more. 
Moreover, uridine monophosphate is uridine bound to a substance called phosphoric acid that helps the body create phosphatidylcholine, which is an essential building block for nerve cells (neurons).
We want our brains to be able to produce optimal amounts of phosphatidylcholine, and especially when we’re also supplementing with natural brain growth agents like bacopa monnieri (also in ASCEND).
While human research on uridine is currently sparse, the data we do have suggests that it can...
- Increase the growth of neurons. 
- Protect the brain from oxidative damage, which can improve memory by preventing a decrease in cognition. 
- Sustain memory during periods of minimal mental stimulation. 
- Reduce the time it takes to fall asleep and improve sleep quality. 
In case you're wondering why we've included an ingredient based on animal research alone, uridine is a vital nutrient for brain growth. It’s used to make neuron membranes and is a limiting factor in how many neurons can be produced at any given time (the more uridine there is in your body, the faster and better your brain can repair itself). 
Thus, it's no surprise that, when supplemented, it can produce cognitive benefits in rodents, and we strongly believe that these effects will be replicated to some degree in humans as more research is done.
The clinically effective dosage of uridine hasn’t been established yet, but ASCEND contains 250 milligrams as it’s the human equivalent to what is required to produce the desired effects in animal research.
Bacopa monnieri is an herb that has long been used in traditional Ayurvedic medicine to treat various neurological health disorders and to aid memory.
Modern science has discovered why: it contains bacosides, which are natural substances that stimulate the secretion of two types of brain growth factors (BDNF and NGF), which are chemicals in the brain that help neurons connect, grow, and proliferate.
Research shows that supplementation with bacopa monnieri can...
- Improve cognition and memory performance, particularly with working memory (keeping things in mind even when not focused on them, until you can pass them to short-term memory banks). 
- Improve mood and reduce stress and depressive symptoms. 
Clinically effective dosages of bacopa monnieri range from 250 to 300 milligrams standardized for 55% bacoside content, and ASCEND contains 330 milligrams at 50% bacosides as this is the level used in many clinical trials showing efficacy.
Agmatine is a “chemical messenger” of the nervous system (neurotransmitter) that helps protect nerve cells against damage and interacts with the pain and pleasure pathways in the brain.
Neurons can’t grow and sustain themselves while under duress, and while agmatine isn’t necessarily an antioxidant, it can limit the damage caused to neurons by various stressors. 
Agmatine is an interesting molecule in that it provides only mild benefits on its own, but really shines as a synergist with other nootropics (it makes certain types of compounds much more effective).
In addition to its synergistic effects, research shows that supplementation with agmatine can...
- Enhance the activity of serotonin in the brain, which can also help serotonin-based supplements or drugs become more effective. 
- Mitigate the decrease in neurotransmitters and subsequent depressive symptoms caused by stress. 
We’re partly relying on animal research with agmatine because while it lacks human studies for our purposes here, cognitive effects have been demonstrated in the rodent model and based on the human studies currently available, we believe they can likely be extrapolated to us, as well.
The clinically effective dosage of agmatine hasn’t been established yet, but up to 3.5 grams has been shown to be safe in humans and the nootropic range (based on animal research) appears to be between 1.6 to 6.4 milligrams per kilogram of body weight, so 110 to 440 milligrams for a 150-pound person. 
ASCEND contains 500 milligrams of agmatine, which is enough to safely reap its cognitive benefits.
Place Your Order Now
Place your order now and if you don’t absolutely love it, just let us know and we’ll give you a full refund on the spot. No complicated forms and no return necessary. You really can’t lose, so order now and get ready for more focus, cognitive fluency, and positive feelings.
Ophir E, Nass C, Wagner AD. - Proc Natl Acad Sci U S A. 2009;106(37):15583-15587. doi:10.1073/pnas.0903620106. ↑
Ziegenfuss T, Landis J, Hofheins J. - J Int Soc Sports Nutr. 2008;5(Suppl 1):P15. doi:10.1186/1550-2783-5-S1-P15. ↑
De Jesus Moreno Moreno M. - Clin Ther. 2003;25(1):178-193. ↑
Kawamura T, Okubo T, Sato K, et al. - Nutrition. 2012;28(11-12):1122-1126. doi:10.1016/j.nut.2012.02.011. ↑
Marcus L, Soileau J, Judge LW, Bellar D. - Journal of the International Society of Sports Nutrition. 2017;14:39. doi:10.1186/s12970-017-0196-5. ↑
Alvarez XA, Laredo M, Corzo D, et al. - Methods Find Exp Clin Pharmacol. 1997;19(3):201-210. ↑
Spiers PA, Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ. - Arch Neurol. 1996;53(5):441-448. ↑
Brown ES, Gorman AR, Hynan LS. - J Clin Psychopharmacol. 2007;27(5):498-502. doi:10.1097/JCP.0b013e31814db4c4. ↑
McGlade E, Locatelli A, Hardy J, et al. - Food Nutr Sci. 2012;3(6):769-773. doi:10.4236/fns.2012.36103. ↑
Wurtman RJ, Regan M, Ulus I, Yu L. - Biochem Pharmacol. 2000;60(7):989-992. ↑
Phan C-W, David P, Wong K-H, Naidu M, Sabaratnam V. Gallyas F, ed. - PLoS One. 2015;10(11):e0143004. doi:10.1371/journal.pone.0143004. ↑
Koyuncuoglu T, Turkyilmaz M, Goren B, Cetinkaya M, Cansev M, Alkan T. - Restor Neurol Neurosci. 2015;33(5):777-784. doi:10.3233/RNN-150549. ↑
Cansev M, Minbay Z, Goren B, et al. - Neurosci Lett. 2013;542:65-70. doi:10.1016/j.neulet.2013.02.035. ↑
Goren B, Cakir A, Ocalan B, et al. - Brain Res. 2017;1659:81-87. doi:10.1016/j.brainres.2017.01.026. ↑
Teather LA, Wurtman RJ. - J Nutr. 2006;136(11):2834-2837. ↑
Honda K, Okano Y, Komoda Y, Inoue S. - Neurosci Lett. 1985;62(1):137-141. doi:10.1016/0304-3940(85)90297-6. ↑
Honda K, Komoda Y, Nishida S, et al. - Neurosci Res. 1984;1(4):243-252. ↑
Cansev M. - NeuroMolecular Med. 2016;18(3):426-440. doi:10.1007/s12017-016-8414-x. ↑
Peth-Nui T, Wattanathorn J, Muchimapura S, et al. - Evidence-Based Complement Altern Med. 2012;2012:1-10. doi:10.1155/2012/606424. ↑
Morgan A, Stevens J. - Results of a Randomized, Placebo-Controlled, Double-Blind Trial. J Altern Complement Med. 2010;16(7):753-759. doi:10.1089/acm.2009.0342. ↑
Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. - J Ethnopharmacol. 2014;151(1):528-535. doi:10.1016/j.jep.2013.11.008. ↑
Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. - J Altern Complement Med. 2012;18(7):647-652. doi:10.1089/acm.2011.0367. ↑
Calabrese C1, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. - Helfgott Research Institute, National College of Natural Medicine ↑
Benson S, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A. - Phyther Res. 2014;28(4):551-559. doi:10.1002/ptr.5029. ↑
Lee WT, Hong S, Yoon SH, et al. - Brain Res. 2009;1281:64-70. doi:10.1016/j.brainres.2009.05.046. ↑
Taksande BG, Kotagale NR, Tripathi SJ, Ugale RR, Chopde CT. - Neuropharmacology. 2009;57(4):415-424. doi:10.1016/j.neuropharm.2009.06.035. ↑
Freitas AE, Egea J, Buendia I, et al. - Mol Neurobiol. 2016;53(5):3030-3045. doi:10.1007/s12035-015-9182-6. ↑
Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. - Pain Med. 2010;11(3):356-368. doi:10.1111/j.1526-4637.2010.00808.x. ↑
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Ingredients & Use
To support cognitive health and performance, supplement with one serving of ASCEND every day, preferably with food. You can take a full serving all at once or split it into two equal doses taken several hours apart (we recommend that you try both ways and see which you like best).
Not intended for use by persons under the age of 18. Do not exceed recommended dose. Consult your physician prior to use if you are pregnant or nursing, or if you are at risk, have been diagnosed, or are being treated for high blood pressure, heart, kidney, or thyroid, anxiety, depression, seizure disorder, or stroke.
KEEP OUT OF REACH OF CHILDREN. STORE IN A COOL DRY PLACE AND AVOID EXCESSIVE HEAT.