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Legion Berberine Ingredient (1,500 milligrams per serving)

Berberine (1,500 milligrams per serving)

Berberine is a naturally occurring substance found in several plants, including Berberis species and Coptis chinensis. It has long been used in Chinese and Ayurvedic medicine to support digestive and metabolic health.

Berberine activates AMPK—an enzyme that regulates how your cells use energy—which may help support metabolic health as well as healthy cholesterol and triglyceride levels.[6][7][8][9][10]

It may also increase energy expenditure by activating brown fat, a type of fat that burns energy to produce heat.[11]

Research shows that supplementation with berberine . . .

The clinically effective dose of berberine is between 1,000 and 1,500 milligrams per day, typically split into 2 or 3 doses.

Caffeine

No Artificial Food Dyes, Fillers, or Other Unnecessary Junk

Artificial food dyes and fillers may not be as dangerous as some people claim, but studies show they can cause negative effects in some people, including gastrointestinal toxicity and behavioral disorders.[22][23][24][25][26]

That’s why we use natural coloring derived from fruits and other foods as well as naturally derived ingredients for enhancing shelf life and facilitating the manufacturing process.

No Artificial Food Dyes or Other Chemical Junk

Third-Party Lab Tested for Purity and Accuracy

Our berberine is third-party lab tested for purity and accuracy and certified to meet or exceed FDA safety guidelines.[27]

Lab-Tested for Purity and Accuracy

Made in the USA with Globally Sourced Ingredients

If you want to ensure the supplements you’re swallowing every day are safe and effective, you want to buy from a company that:

  1. Sources ingredients from premium suppliers around the world (great supplements require great raw materials)
  2. Tests all products for purity and accuracy in accredited laboratories (to conclusively verify safety and efficacy)
  3. Manufactures in America, which has some of the strictest regulations in the world

And that’s exactly what we do here at Legion.

See how Legion Berberine compares to the rest.

  • Active Ingredient
    Per Serving
  • Clinically Effective Ingredient
    & Dose
  • Third-Party Lab-Tested for Purity
  • Labdoor™ Certified Brand
  • Price Per Serving
  • Price Per Gram
  • Legion
    Berberine

    Legion Berberine
  • 1,500 mg
    per serving
  • True
  • True
  • True
  • Thorne
    Berberine

    Thorne Berberine
  • 200 mg
    per serving
  • False
  • True
  • False
  • $0.50
  • $2.50
  • Pure
    Encapsulations
    Berberine

    Pure Encapsulations Berberine
  • 550 mg
    per serving
  • False
  • Question Mark
  • False
  • $0.86
  • $1.56
  • Sports Research
    Berberine

    Sports Research Berberine
  • 500 mg
    per serving
  • False
  • Question Mark
  • False
  • $0.33
  • $0.67
Legion Berberine Certificate of Analysis

The #1 brand of naturally sweetened and flavored sports supplements.

We’ve sold over 5 million bags and bottles to over 1 million customers in 169 countries who have left us over 55,000 5-star reviews.

Science-Backed Ingredients
Clinically Effective Ingredient and Dose

The active ingredient, form, and dose in our berberine is backed by peer-reviewed scientific research demonstrating clear benefits in healthy humans.

Total Label Transparency
Total Label Transparency

We clearly list the dose of each ingredient on our berberine label—no proprietary blends or hidden ingredients—so you can verify our formulation’s validity and effectiveness.

Lab Tested
Third-Party Lab Tested for Purity and Accuracy

Our berberine is third-party lab tested for purity and accuracy and certified to meet or exceed FDA safety guidelines.

Natural Ingredients
No Unnecessary Junk

Our berberine contains no artificial food dyes, fillers, or other unnecessary junk.

Made in USA
Made in the USA

Our berberine is made in America with globally sourced ingredients in NSF-certified, FDA-inspected facilities that adhere to Current Good Manufacturing Practice (cGMP) standards.

100% Money-Back-Guarantee
100% Money-Back Guarantee

If you don't absolutely love our berberine, you get a prompt and courteous refund. No forms or returns necessary.

Trusted by scientists, doctors, and everyday fitness folk alike.

Previous
  • Dr. Bill Campbell, PhD

    "Legion is science-based at its core. Not only do they dose all of their products based on the clinical doses proven to be effective by scientific studies, they go above and beyond the their competitors by funding new research."

    Dr. Bill Campbell, PhD

    Professor of Exercise Science at University of South Florida
  • Dr. Spencer Nadolsky, MD

    "There are a lot of sleazy supplement companies out there, but Legion is not one of them. Their products are free of fillers and inactive ingredients and they take the time (and money) to test them with independent labs to ensure you're getting what you pay for."

    Dr. Spencer Nadolsky, MD

    Board-Certified Family Medicine Physician and a Diplomate of the American Board of Obesity Medicine
  • Sal Di Stefano, Justin Andrews, and Adam Schafer

    "When it comes to quality and integrity, Legion is among the best. Their products only include ingredients that are backed by research and in doses that are proven to be effective in scientific studies."

    Sal Di Stefano, Justin Andrews, and Adam Schafer

    Hosts of The Mind Pump Podcast
  • Jordan Syatt

    "Legion is a tremendous company run by people I trust and respect. The quality of their supplements is second to no one. And while I don’t use many supplements, the only ones I do come from Legion."

    Jordan Syatt

    Strength and Nutrition Coach
  • Menno Henselmans, MS

    "Legion consults with nutrition experts to make honest, science-based products and then proves they're genuine with independent lab work. That's how all supplement companies should operate."

    Menno Henselmans, MS

    Founder of Bayesian Bodybuilding, Published Scientist, and Physique Coach
  • Sports Illustrated Sports Illustrated

    "Legion's customers are getting some of the best sports supplements on the market."

  • Healthline Healthline

    "Legion Pulse is the best overall pre-workout, especially for energy and focus."

  • Forbes Health Forbes Health

    "Legion Pulse is the best pre-workout of 2024."

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Frequently Asked Questions

How do I use your berberine?
Can I take berberine on an empty stomach?
What type of effects should I notice when I take your berberine?
What makes your berberine supplement different from other berberine supplements on the market?
Can I take your berberine with other supplements or medications?
Is your berberine gluten-free, vegetarian, or vegan?
What does the Prop65 warning on the labels mean?

+References

A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.

Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. Eur J Endocrinol. 2012;166(1):99-105.

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.

Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, et al. PLoS One. 2015;10(8):e0134172.

Metformin and Berberine, Two Versatile Drugs in Treatment of Common Metabolic Diseases.

Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Oncotarget. 2017;9(11):10135-10146.

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease.

Och A, Och M, Nowak R, Podgorska D, Podgorski R. Molecules. 2022;27(4):1351.

Berberine Promotes the Recruitment and Activation of Brown Adipose Tissue in Mice and Humans.

Wu L, Xia M, Duan Y, Zhang L, Jiang H, Hu X, Yan H, Zhang Y, Gu Y, Shi H, et al. Cell Death Dis. 2019;10(6):468.

A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.

Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. Eur J Endocrinol. 2012;166(1):99-105.

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.

Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, et al. PLoS One. 2015;10(8):e0134172.

Metformin and Berberine, Two Versatile Drugs in Treatment of Common Metabolic Diseases.

Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Oncotarget. 2017;9(11):10135-10146.

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease.

Och A, Och M, Nowak R, Podgorska D, Podgorski R. Molecules. 2022;27(4):1351.

A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome.

Wei W, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. Eur J Endocrinol. 2012;166(1):99-105.

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease.

Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, Zeng MS, Tu YF, Feng R, Jia WP, et al. PLoS One. 2015;10(8):e0134172.

Metformin and Berberine, Two Versatile Drugs in Treatment of Common Metabolic Diseases.

Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Oncotarget. 2017;9(11):10135-10146.

Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease.

Och A, Och M, Nowak R, Podgorska D, Podgorski R. Molecules. 2022;27(4):1351.

Toxicological Significance of Azo Dye Metabolism by Human Intestinal Microbiota.

Feng J, Cerniglia CE, Chen H. Front Biosci (Elite Ed). 2012;4(2):568-586. Published 2012 Jan 1. doi:10.2741/e400.

Artificial Food Dyes and Attention Deficit Hyperactivity Disorder.

Kanarek RB. Nutr Rev. 2011;69(7):385-391. doi:10.1111/j.1753-4887.2011.00385.x.

Meta-analysis of Attention-Deficit/Hyperactivity Disorder Symptoms, Restriction Diet, and Synthetic Food Color Additives.

Nigg JT, Lewis K, Edinger T, Falk M. J Am Acad Child Adolesc Psychiatry. 2012;51(1):86-97.e8. doi:10.1016/j.jaac.2011.10.015.

Food Additives and Hyperactive Behaviour in 3-Year-Old and 8/9-Year-Old Children in the Community: A Randomised, Double-Blinded, Placebo-Controlled Trial.

McCann D, Barrett A, Cooper A, et al. Lancet. 2007;370(9598):1560-1567. doi:10.1016/S0140-6736(07)61306-3.

Effect of Food Azo Dye Tartrazine on Learning and Memory Functions in Mice and Rats, and the Possible Mechanisms Involved.

Gao Y, Li C, Shen J, Yin H, An X, Jin H. J Food Sci. 2011;76(6):T125-T129. doi:10.1111/j.1750-3841.2011.02267.x.