This podcast is going to cover a technical aspect of muscle building. I’m discussing which is more important for getting bigger and stronger: hypertrophy or hyperplasia?
What do those words even mean?
Well, hypertrophy is when your muscle cells get bigger, and hyperplasia is when the number of muscle cells increases.
Scientists aren’t sure whether hyperplasia even happens in humans, but “believers” contend that both hypertrophy and hyperplasia contribute to muscle growth. Thus, according to them, you should train to produce both of these phenomena to gain muscle as quickly as possible.
Focusing on hypertrophy or hyperplasia would change how you train, so this topic has practical applications I’m going to break down for you in this podcast.
Lastly, if you want to support the show, please drop a quick review of it over on iTunes. It really helps!
4:27 – What is hypertrophy?
4:46 – What are the components of muscle?
4:56 – What is myofibrilar hypertrophy?
5:16 – What is muscle hyperplasia?
5:37 – Does hyperplasia happen in humans?
7:16 – Does hyperplasia exist?
8:10 – How do you induce hyperplasia in animals?
9:26 – What does the science say about hyperplasia in humans?
16:56 – How do we cause hypertrophy?
18:28 – Why does training near failure produce hypertrophy?
19:06 – What about hyperplasia and training?
20:12 – Does stretching cause hyperplasia?
Mentioned on the Show:
What did you think of this episode? Have anything else to share? Let me know in the comments below!
+ Scientific References
- BJ, S. (2010). The mechanisms of muscle hypertrophy and their application to resistance training. Journal of Strength and Conditioning Research, 24(10), 2857–2872. https://doi.org/10.1519/JSC.0B013E3181E840F3
- SE, A., PK, W., ME, D., & WJ, G. (1989). Regionalized adaptations and muscle fiber proliferation in stretch-induced enlargement. Journal of Applied Physiology (Bethesda, Md. : 1985), 66(2), 771–781. https://doi.org/10.1152/JAPPL.19126.96.36.1991
- JA, C., & FW, B. (1998). Myogenin mRNA is elevated during rapid, slow, and maintenance phases of stretch-induced hypertrophy in chicken slow-tonic muscle. Pflugers Archiv : European Journal of Physiology, 435(6), 850–858. https://doi.org/10.1007/S004240050593
- D, D. J., V, J., & W, H. (2015). Intermittent stretch training of rabbit plantarflexor muscles increases soleus mass and serial sarcomere number. Journal of Applied Physiology (Bethesda, Md. : 1985), 118(12), 1467–1473. https://doi.org/10.1152/JAPPLPHYSIOL.00515.2014
- M, N., A, Y., S, N., T, N., T, Y., M, I., K, M., H, O., & S, N. (2002). A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle. Biochemical and Biophysical Research Communications, 293(1), 247–251. https://doi.org/10.1016/S0006-291X(02)00209-7
- PD, G., BF, T., RL, M., & M, R. (1981). Muscular enlargement and number of fibers in skeletal muscles of rats. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 50(5), 936–943. https://doi.org/10.1152/JAPPL.19188.8.131.526
- W, G., GC, E., & F, B.-P. (1977). Skeletal muscle fiber splitting induced by weight-lifting exercise in cats. Acta Physiologica Scandinavica, 99(1), 105–109. https://doi.org/10.1111/J.1748-1716.1977.TB10358.X
- Higgins, P. J., & Thorpe, J. E. (1990). Hyperplasia and hypertrophy in the growth of skeletal muscle in juvenile Atlantic salmon, Salmo salar L. Journal of Fish Biology, 37(4), 505–519. https://doi.org/10.1111/J.1095-8649.1990.TB05884.X
- J Antonio, & W J Gonyea. (n.d.). Muscle fiber splitting in stretch-enlarged avian muscle - PubMed. Retrieved September 7, 2021, from https://pubmed.ncbi.nlm.nih.gov/7968431/
- D’Antona, G., Lanfranconi, F., Pellegrino, M. A., Brocca, L., Adami, R., Rossi, R., Moro, G., Miotti, D., Canepari, M., & Bottinelli, R. (2006). Skeletal muscle hypertrophy and structure and function of skeletal muscle fibres in male body builders. The Journal of Physiology, 570(Pt 3), 611. https://doi.org/10.1113/JPHYSIOL.2005.101642
- L, L., & PA, T. (1986). Motor unit fibre density in extremely hypertrophied skeletal muscles in man. Electrophysiological signs of muscle fibre hyperplasia. European Journal of Applied Physiology and Occupational Physiology, 55(2), 130–136. https://doi.org/10.1007/BF00714994
- SE, A., WH, G., WJ, G., & J, S.-G. (1989). Contrasts in muscle and myofibers of elite male and female bodybuilders. Journal of Applied Physiology (Bethesda, Md. : 1985), 67(1), 24–31. https://doi.org/10.1152/JAPPL.19184.108.40.206
- JD, M., DG, S., SE, A., & JR, S. (1984). Muscle fiber number in biceps brachii in bodybuilders and control subjects. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 57(5), 1399–1403. https://doi.org/10.1152/JAPPL.19220.127.116.119
- T, H., E, J., & B, S. (1978). Cross-sectional area of the thigh muscle in man measured by computed tomography. Scandinavian Journal of Clinical and Laboratory Investigation, 38(4), 355–360. https://doi.org/10.3109/00365517809108434
- P, S., ER, F., P, N., & A, T. (1981). The relationship between the mean muscle fibre area and the muscle cross-sectional area of the thigh in subjects with large differences in thigh girth. Acta Physiologica Scandinavica, 113(4), 537–539. https://doi.org/10.1111/J.1748-1716.1981.TB06934.X
- F, K., A, E., S, H., & LE, T. (1999). Effects of anabolic steroids on the muscle cells of strength-trained athletes. Medicine and Science in Sports and Exercise, 31(11), 1528–1534. https://doi.org/10.1097/00005768-199911000-00006
- Yu, J.-G., Bonnerud, P., Eriksson, A., Stål, P. S., Tegner, Y., & Malm, C. (2014). Effects of Long Term Supplementation of Anabolic Androgen Steroids on Human Skeletal Muscle. PLoS ONE, 9(9), 105330. https://doi.org/10.1371/JOURNAL.PONE.0105330
- M, S., J, L., A, E., & CC, T. (1991). Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? A left-right comparison of the fibre number in whole anterior tibialis muscles. European Journal of Applied Physiology and Occupational Physiology, 62(5), 301–304. https://doi.org/10.1007/BF00634963
- L, B., & HG, B. (1963). Lateral dominance and right-left awareness in normal children. Child Development, 34, 257–270. https://doi.org/10.1111/J.1467-8624.1963.TB05137.X
- AR, F.-M., L, G., & Y, B. (1980). Isokinetic and static plantar flexion characteristics. European Journal of Applied Physiology and Occupational Physiology, 45(2–3), 221–234. https://doi.org/10.1007/BF00421330
- NA, T., & JG, W. (1986). Exercise-induced skeletal muscle growth. Hypertrophy or hyperplasia? Sports Medicine (Auckland, N.Z.), 3(3), 190–200. https://doi.org/10.2165/00007256-198603030-00003
- E, B., & B, E. (1982). The needle biopsy technique for fibre type determination in human skeletal muscle--a methodological study. Acta Physiologica Scandinavica, 116(4), 437–442. https://doi.org/10.1111/J.1748-1716.1982.TB07163.X
- J, L., K, H.-L., & M, S. (1983). Distribution of different fibre types in human skeletal muscles. 2. A study of cross-sections of whole m. vastus lateralis. Acta Physiologica Scandinavica, 117(1), 115–122. https://doi.org/10.1111/J.1748-1716.1983.TB07185.X
- E R Helms, P J Fitschen, A A Aragon, J Cronin, & B J Schoenfeld. (n.d.). Recommendations for natural bodybuilding contest preparation: resistance and cardiovascular training - PubMed. Retrieved September 7, 2021, from https://pubmed.ncbi.nlm.nih.gov/24998610/
- BJ, S., D, O., & JW, K. (2017). Dose-response relationship between weekly resistance training volume and increases in muscle mass: A systematic review and meta-analysis. Journal of Sports Sciences, 35(11), 1073–1082. https://doi.org/10.1080/02640414.2016.1210197
- A L Goldberg, J D Etlinger, D F Goldspink, & C Jablecki. (n.d.). Mechanism of work-induced hypertrophy of skeletal muscle - PubMed. Retrieved September 7, 2021, from https://pubmed.ncbi.nlm.nih.gov/128681/
- Graham, Z. A., Gallagher, P. M., & Cardozo, C. P. (2015). Focal adhesion kinase and its role in skeletal muscle. Journal of Muscle Research and Cell Motility, 36(0), 305. https://doi.org/10.1007/S10974-015-9415-3
- Yoon, M.-S. (2017). mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass. Frontiers in Physiology, 8(OCT), 788. https://doi.org/10.3389/FPHYS.2017.00788
- CL, S., BDH, K., MR, B., GR, J., & JM, J. (2017). Stretch training induces unequal adaptation in muscle fascicles and thickness in medial and lateral gastrocnemii. Scandinavian Journal of Medicine & Science in Sports, 27(12), 1597–1604. https://doi.org/10.1111/SMS.12822
- GR, M., DW, W., & K, B. (2015). The molecular basis for load-induced skeletal muscle hypertrophy. Calcified Tissue International, 96(3), 196–210. https://doi.org/10.1007/S00223-014-9925-9
- G, M., CI, M., A, B., K, W., & GL, O. (2014). Muscular adaptations and insulin-like growth factor-1 responses to resistance training are stretch-mediated. Muscle & Nerve, 49(1), 108–119. https://doi.org/10.1002/MUS.23884