Nitric oxide supplements hit the bodybuilding scene about a decade ago, and they hit the ground running.
The first one to make waves was called “NO2.”
It became an overnight bestseller, and was quickly followed by a pile of “me too” products, which only served to further ratchet up the nitric oxide hype.
How true is all of this, though?
Do nitric oxide supplements really work, or are they just a waste of money, like most bodybuilding supplements?
Well, you’re going to find out in this article.
We’re going to look at what nitric oxide is, what these supplements are comprised of, what science has to say about their effectiveness, and more.
Let’s start at the top.
- What Is Nitric Oxide?
- What Is a Nitric Oxide Supplement?
- The Benefits of Nitric Oxide Supplements
- The Best Nitric Oxide Supplements
- The Bottom Line on Nitric Oxide Supplements
Table of Contents
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Nitric oxide is a simple molecule made up of one nitrogen atom attached to one oxygen atom.
It’s gaseous, and its primary role in the body is helping cells communicate with one another.
This is now just a mundane fact, but it was a pretty big discovery (Nobel prize-winning big) because previously, nobody knew that cells could produce gasses and float them to one another.
Despite the name, nitric oxide supplements don’t contain nitric oxide.
Instead, they contain natural ingredients that increase the production of nitric oxide in the body.
For example, one of the substances most often found in these supplements is the amino acid L-arginine, which is a good source of nitrogen and thus can influence nitric oxide production (nitrogen is needed to create nitric oxide, so the more that’s available to the body, the more NO it can produce).
Most nitric oxide supplements are sold as muscle builders.
This is a powerful hook, and it’s not wholly unreasonable.
Furthermore, studies show that these supplements can increase the production of growth hormone in response to exercise, which is music to many gymgoers’ ears.
More growth hormone naturally means more muscle growth, right?
Unfortunately, that’s not how it plays out.
And this is especially true when we’re talking natural fluctuations of GH, as opposed to injecting large amounts of synthetic hormones.
If you want simple evidence of this, consider consider a study conducted by researchers at McMaster University.
What they found is that exercise did spike certain hormones, like testosterone, growth hormone, and IGF-1, but a) the spikes were rather small, and b) their magnitude had no effect on muscle and strength gains.
In other words, hormones didn’t change as much as expected, and the guys that experienced larger hormonal increases made or less the same gains as those that experienced smaller ones.
So, if that’s a summary of what nitric oxide supplements can’t do for you, what can they do?
This is why many people report experiencing bigger and better “pumps” in the gym when they take nitric oxide supplements (more blood flow = bigger pumps).
There’s also evidence that they can improve exercise performance, which can translate into greater strength and muscle gains over time (if you actually use them to push yourself harder in your workouts).
So far I’ve mentioned just one nitric oxide supplement: L-arginine.
I’ve also mentioned that it’s the most popular one on the market, but that’s not because it’s the best. In fact, research shows it’s rather unreliable, working well in some people and not at all in others.
This helps explain why one person will swear by one nitric oxide supplement or another while someone else will experience no effects or benefits whatsoever.
Luckily, there are other options, and the best is another amino acid called L-citrulline.
L-citrulline is converted into arginine in the kidneys, and results in longer and larger elevations of plasma (blood) arginine levels than supplementing with arginine itself. It also elevates plasma levels of another amino acid, ornithine, which reduces exercise-induced fatigue.
If you want to try L-citrulline for yourself, check out my 100% natural pre-workout supplement PULSE.
It contains a clinically effective dose of 8 grams of citrulline malate in every serving, along with effective dosages of 5 other ingredients proven to increase physical and mental performance:
Theanine is an amino acid found mainly in tea that reduces the effects of mental and physical stress, increases the production of nitric oxide, and improves alertness, focus, attention, memory, mental task performance, and mood.
Equally important to what’s in PULSE is what’s not in it.
Namely, it contains…
- No artificial sweeteners or flavors.
- No artificial food dyes.
- No unnecessary fillers, carbohydrate powders, or junk ingredients.
The bottom line is if you want to feel focused, tireless, and powerful in your workouts…and if you want to say goodbye to the pre-workout jitters, upset stomachs, and crashes for good…then you want to try PULSE.
If you have a budget for “non-essential” supplements, then a good nitric oxide supplement is worth considering.
And especially if you want to do everything you can to get the most from your training.
It’s not going to supercharge your strength or muscle building, but research clearly shows that raising plasma nitric oxide levels can improve your workout performance.
If you take advantage of that and push yourself harder than you otherwise could, that can mean better progress over time.
I also have to admit that big pumps are kind of cool, too. 🙂
What’s your take on nitric oxide supplements? Have anything else to share? Let me know in the comments below!
+ Scientific References
- West, D. W. D., & Phillips, S. M. (2012). Associations of exercise-induced hormone profiles and gains in strength and hypertrophy in a large cohort after weight training. European Journal of Applied Physiology, 112(7), 2693–2702. https://doi.org/10.1007/s00421-011-2246-z
- Liu, H., Bravata, D. M., Olkin, I., Friedlander, A., Liu, V., Roberts, B., Bendavid, E., Saynina, O., Salpeter, S. R., Garber, A. M., & Hoffman, A. R. (2008). Systematic review: The effects of growth hormone on athletic performance. In Annals of Internal Medicine (Vol. 148, Issue 10, pp. 747–758). American College of Physicians. https://doi.org/10.7326/0003-4819-148-10-200805200-00215
- Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., Smith, K., Reitelseder, S., Kappelgaard, A. M., Rasmussen, M. H., Flyvbjerg, A., & Kjaer, M. (2010). Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. Journal of Physiology, 588(2), 341–351. https://doi.org/10.1113/jphysiol.2009.179325
- Kanaley, J. A. (2008). Growth hormone, arginine and exercise. In Current Opinion in Clinical Nutrition and Metabolic Care (Vol. 11, Issue 1, pp. 50–54). Curr Opin Clin Nutr Metab Care. https://doi.org/10.1097/MCO.0b013e3282f2b0ad
- Biolo, G., Maggi, S. P., Williams, B. D., Tipton, K. D., & Wolfe, R. R. (1995). Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans. American Journal of Physiology - Endocrinology and Metabolism, 268(3 31-3). https://doi.org/10.1152/ajpendo.1995.268.3.e514
- Bednarz, B., Wolk, R., Chamiec, T., Herbaczynska-Cedro, K., Winek, D., & Ceremuzynski, L. (2000). Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. International Journal of Cardiology, 75(2–3), 205–210. https://doi.org/10.1016/S0167-5273(00)00324-7
- Paddon-Jones, D., Børsheim, E., & Wolfe, R. R. (2004). Potential ergogenic effects of arginine and creatine supplementation. Journal of Nutrition, 134(10 SUPPL.). https://doi.org/10.1093/jn/134.10.2888s
- Álvares, T. S., Meirelles, C. M., Bhambhani, Y. N., Paschoalin, V. M. F., & Gomes, P. S. C. (2011). L-arginine as a potential ergogenic aid in healthy subjects. In Sports Medicine (Vol. 41, Issue 3, pp. 233–248). Springer International Publishing. https://doi.org/10.2165/11538590-000000000-00000