Ascend | Nootropic

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Our "It's On Us" 100% Money-Back Guarantee

If you don’t absolutely love our stuff for whatever reason, we don’t request you deliver it to a PO box in the Gobi Desert by carrier pigeon.

Nor do we ask you to fill a cursed inkwell with orc’s blood and demon saliva and with it complete reams of return forms written in ancient Cyrillic script.

We just . . . wait for it . . . give you your money back. No returns. No forms. No nonsense. Holy moo cows.

That means you can say “yes” now and decide later. You really have nothing to lose.

Why International Bestselling Author Mike Matthews Created Ascend

Ascend is a nootropic (“brain booster”) that enhances focus, memory, mental speed, creativity, mood, and overall brain health.

How much joy and satisfaction you get from life depends in large part on how well you can focus, think, and remember.

That’s why anyone who wants to optimize their mental health and performance should limit their exposure to always-on technologies, eat plenty of nutritious, relatively unprocessed foods, exercise regularly, and get enough sleep.

Supplementation can help as well, and that’s why we created Ascend.

The reason it’s so effective is simple:

Every ingredient is backed by peer-reviewed scientific research and is included at clinically effective levels.

So, if you want to banish “foggy brain” and think faster, focus deeper, and feel better . . . you want to try Ascend today.

You won’t be disappointed.

In fact, if you don’t absolutely love Ascend, just let us know and we’ll give you a full refund on the spot. No form or return necessary.

You really can’t lose, so order now, and try Ascend risk-free and see if it’s for you.

Science-Backed Ingredients
Science-Backed Ingredients

Every ingredient in Ascend is backed by peer‑reviewed scientific research demonstrating clear benefits.

Clinically Effective Doses
Clinically Effective Doses

Every ingredient is also included at clinically effective levels, which are the doses used in published scientific studies.

Naturally Sweetened & Flavored
All-Natural Ingredients

Ascend contains no artificial ingredients like sweeteners, food dyes, or other unwanted chemicals.

Lab Tested
Lab Tested

Every ingredient in every bottle of Ascend is tested for heavy metals, microbes, allergens, and other contaminants to ensure they meet FDA purity standards.

Made in USA
Made in the USA

Ascend is proudly made in America in NSF‑certified and FDA-inspected manufacturing facilities.

100% Money-Back-Guarantee
100% Money-Back-Guarantee

If you don't absolutely love Ascend, just let us know, and you’ll get a prompt and courteous refund. No forms or returns necessary.

Ingredients (2,180 mg per serving)

Alpha-GPC (300 mg per serving)

Alpha-glycerophosphocholine (also known as alpha-GPC and glycerophosphocholine) is a compound of two molecules: choline and glycerophosphate.

Choline is a nutrient that’s vital for brain health and function, and glycerophosphate is a substance found in the membrane of neurons (nerve cells) that helps transport choline to the brain.

When ingested, alpha-GPC increases the activity of a chemical in the brain known as acetylcholine, which is used by nerves to communicate with each other and provides the brain with glycerophosphate, which can improve its health and function.

Research shows that supplementation with alpha-GPC . . .

  • Increases power output[1]
  • Protects against cognitive decline as we age[2]
  • Increases growth hormone levels[3]

The clinically effective dose of alpha-GPC is between 150 and 1,200 milligrams, with 250 to 500 milligrams sufficient for cognitive benefits and higher doses required for affecting dementia.[4]

Alpha-GPC

Avena Sativa (800 mg per serving)

Avena sativa is a plant whose stem and leaves have long been used to treat psychological maladies such as insomnia and anxiety.

Research shows that it positively influences brain function in a variety of ways, which is why studies show that supplementation with Avena sativa . . .

  • Boosts cognitive performance and “mental fitness” (even in people with compromised cognitive function)[5][6]
  • Increases executive function (controlling your mind and behavior)[7]
  • Enhances spatial working memory (short-term memory of information related to locations)[8]
  • Increases alertness and learning performance[9]
  • Reduces the negative effects of multitasking on cognitive performance[10]

Research also shows that while a single dose of Avena sativa can provide benefits, results may improve with continued use.[11][12]

The clinically effective dose of Avena sativa is between 800 and 1,600 mg, with most of the benefits occurring at the lower end of this range.[13][14]

Avena Sativa

Uridine Monophosphate (250 mg per serving)

Uridine monophosphate is a compound of two molecules: uridine and phosphoric acid.

Uridine is a substance known as a nucleotide that’s involved in the production of the genetic material ribonucleic acid (RNA) and that supports and enhances the growth and function of neurons (nerve cells).[15][16]

Phosphoric acid is a substance that helps the body create phosphatidylcholine.

While human research on uridine is currently sparse, the data we do have suggests that it can . . .

  • Enhance neuron growth[17]
  • Preserve memory by protecting the brain from damage[18][19][20]
  • Reduce mental fatigue[21]
  • Reduce the time it takes to fall asleep[22]
  • Improve sleep quality[23]

The clinically effective dose of uridine monophosphate hasn’t been established yet, but 250 milligrams is the human equivalent of what has produced benefits in animal research.

Uridine Monophosphate

Bacopa Monnieri (330 mg per serving)

Bacopa monnieri is an herb that has long been used in traditional Ayurvedic medicine to aid memory and treat various neurological disorders.

It contains substances known as bacosides that stimulate the secretion of two types of chemicals in the brain known as brain growth factors (brain-derived neurotrophic factor or BDNF, and nerve growth factor or NGF), which help neurons connect, grow, and proliferate.

Research shows that supplementation with bacopa monnieri . . .

The clinically effective dose of bacopa monnieri is between 200 and 400 milligrams depending on its bacoside content.

Bacopa Monnieri

Agmatine (500 mg per serving)

Agmatine is a chemical produced by the brain and found in some fermented foods.

It helps protect neurons (nerve cells) against damage and interacts with the pain and pleasure pathways in the brain.

While human research on agmatine is currently sparse, the data we do have suggests it can enhance the activity of serotonin in the brain, which can enhance mood and reduce the depressive effects of stress.[31][32]

The clinically effective dose of agmatine hasn’t been established yet, but the nootropic range appears to be between 1.6 and 6.4 milligrams per kilogram of body weight, or 110 to 440 milligrams for a 150-pound person.[33]

Agmatine

No Artificial Food Dyes or Other Chemical Junk

Studies show that artificial food dyes may cause negative effects in some people, including gastrointestinal toxicity and behavioral disorders.[34][35][36][37][38]

No Artificial Food Dyes or Other Chemical Junk

Crossed out beakers with liquid in them

Lab Tested for Potency & Purity

microscope

Lab Tested for Potency & Purity

Every bottle of Ascend is analyzed in a state-of-the-art ISO 17025 accredited lab to verify what is and isn’t in it. That way, you know exactly what you’re getting and putting into your body.

Ascend Lab Test Certificate of Analysis

How to Use Ascend

To support cognitive health and performance, supplement with one serving of Ascend every day, preferably with food. You can take a full serving all at once or split it into two equal doses taken several hours apart (we recommend that you try both ways and see which you like best).

Supplement Facts

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Verified Customer Reviews

Ingredients & Use

Ascend Supplement Facts Ascend Supplement Facts

Directions

To support cognitive health and performance, supplement with one serving of Ascend every day, preferably with food. You can take a full serving all at once or split it into two equal doses taken several hours apart (we recommend that you try both ways and see which you like best).

Warning

Not intended for use by persons under the age of 18. Do not exceed recommended dose. Consult your physician prior to use if you are pregnant or nursing, or if you are at risk, have been diagnosed, or are being treated for high blood pressure, heart, kidney, or thyroid, anxiety, depression, seizure disorder, or stroke.

KEEP OUT OF REACH OF CHILDREN. STORE IN A COOL DRY PLACE AND AVOID EXCESSIVE HEAT.

Frequently Asked Questions

How does Ascend compare to other popular nootropics?
What kind of benefits can I expect from taking Ascend?
Why doesn’t Ascend contain ingredients found in many other nootropics like huperzine-A, vinpocetine, and phosphatidylserine?
Why doesn’t Ascend contain racetams?
Are there any side effects I should know about?
Do you need to “cycle” Ascend?
Will I build a tolerance to Ascend?
Will I experience withdrawal effects if I stop taking Ascend?
Does Ascend contain caffeine?
What does the Prop65 warning on the label mean?
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+Scientific References

1. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.

Ziegenfuss T, Landis J, Hofheins J. J Int Soc Sports Nutr. 2008;5(Suppl 1):P15. doi:10.1186/1550-2783-5-S1-P15.

3. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.

Kawamura T, Okubo T, Sato K, et al. Nutrition. 2012;28(11-12):1122-1126. doi:10.1016/j.nut.2012.02.011.

4. Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance.

Marcus L, Soileau J, Judge LW, Bellar D. Journal of the International Society of Sports Nutrition. 2017;14:39. doi:10.1186/s12970-017-0196-5.

5. Ingested oat herb extract (Avena sativa) changes EEG spectral frequencies in healthy subjects.

Dimpfel W, Storni C, Verbruggen M. J Altern Complement Med. 2011 May;17(5):427-34. doi: 10.1089/acm.2010.0143.

6. Acute Effects of an Avena sativa Herb Extract on Responses to the Stroop Color–Word Test.

Narelle M. Berry, Matthew J. Robinson, Janet Bryan, Jonathan D. Buckley, Karen J. Murphy, and Peter R.C. Howe. The Journal of Alternative and Complementary Medicine. Jul 2011.635-637.

7. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.

Kennedy DO, Jackson PA, Forster J, Khan J, Grothe T, Perrinjaquet-Moccetti T, Haskell-Ramsay CF. Nutr Neurosci. 2017 Feb;20(2):135-151. doi: 10.1080/1028415X.2015.1101304.

8. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.

Kennedy DO, Jackson PA, Forster J, Khan J, Grothe T, Perrinjaquet-Moccetti T, Haskell-Ramsay CF. Nutr Neurosci. 2017 Feb;20(2):135-151. doi: 10.1080/1028415X.2015.1101304.

9. An extract from wild green oat improves rat behaviour.

Schellekens C, Perrinjaquet-Moccetti T, Wullschleger C, Heyne A. Phytother Res. 2009 Oct;23(10):1371-7. doi: 10.1002/ptr.2751.

11. Acute Effects of an Avena sativa Herb Extract on Responses to the Stroop Color–Word Test

Narelle M. Berry, Matthew J. Robinson, Janet Bryan, Jonathan D. Buckley, Karen J. Murphy, and Peter R.C. Howe.The Journal of Alternative and Complementary Medicine.Jul 2011.635-637.

13. Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.

Kennedy DO, Jackson PA, Forster J, Khan J, Grothe T, Perrinjaquet-Moccetti T, Haskell-Ramsay CF. Nutr Neurosci. 2017 Feb;20(2):135-151. doi: 10.1080/1028415X.2015.1101304.

14. Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test.

Berry NM, Robinson MJ, Bryan J, Buckley JD, Murphy KJ, Howe PR. J Altern Complement Med. 2011 Jul;17(7):635-7. doi: 10.1089/acm.2010.0450.

15. The Kennedy pathway-de novo synthesis of phosphatidylethanolamine and phosphatidylcholine.

Gibellini F, Smith TK. IUBMB Life. 2010;62(6):414-428. doi:10.1002/iub.337.

16. Phosphatidylcholine and the CDP-choline cycle.

Fagone P, Jackowski S. Biochim Biophys Acta - Mol Cell Biol Lipids. 2013;1831(3):523-532. doi:10.1016/j.bbalip.2012.09.009.

17. Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism.

Phan C-W, David P, Wong K-H, Naidu M, Sabaratnam V. Gallyas F, ed. PLoS One. 2015;10(11):e0143004. doi:10.1371/journal.pone.0143004.

18 Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats.

Koyuncuoglu T, Turkyilmaz M, Goren B, Cetinkaya M, Cansev M, Alkan T. Restor Neurol Neurosci. 2015;33(5):777-784. doi:10.3233/RNN-150549.

19. Neuroprotective effects of uridine in a rat model of neonatal hypoxic–ischemic encephalopathy.

Cansev M, Minbay Z, Goren B, et al. Neurosci Lett. 2013;542:65-70. doi:10.1016/j.neulet.2013.02.035.

20. Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy.

Goren B, Cakir A, Ocalan B, et al. Brain Res. 2017;1659:81-87. doi:10.1016/j.brainres.2017.01.026.

22. Sleep-promoting effects of intraperitoneally administered uridine in unrestrained rats.

Honda K, Okano Y, Komoda Y, Inoue S. Neurosci Lett. 1985;62(1):137-141. doi:10.1016/0304-3940(85)90297-6.

23. Uridine as an active component of sleep-promoting substance: its effects on nocturnal sleep in rats.

Honda K, Komoda Y, Nishida S, et al. Neurosci Res. 1984;1(4):243-252.

24. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers.

Peth-Nui T, Wattanathorn J, Muchimapura S, et al. Evidence-Based Complement Altern Med. 2012;2012:1-10. doi:10.1155/2012/606424.

25. Does Bacopa monnieri Improve Memory Performance in Older Persons? Results of a Randomized, Placebo-Controlled, Double-Blind Trial.

Morgan A, Stevens J. J Altern Complement Med. 2010;16(7):753-759. doi:10.1089/acm.2009.0342.

26. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.

Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. J Ethnopharmacol. 2014;151(1):528-535. doi:10.1016/j.jep.2013.11.008.

27. The Cognitive-Enhancing Effects of Bacopa monnieri : A Systematic Review of Randomized, Controlled Human Clinical Trials.

Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. J Altern Complement Med. 2012;18(7):647-652. doi:10.1089/acm.2011.0367.

28. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial.

Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. J Altern Complement Med. 2008;14(6):707-713. doi:10.1089/acm.2008.0018.

29. Does bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial.

Morgan A, Stevens J. J Altern Complement Med. 2010;16(7):753-759. doi:10.1089/acm.2009.0342.

30. An Acute, Double-Blind, Placebo-Controlled Cross-over Study of 320 mg and 640 mg Doses of Bacopa monnieri (CDRI 08) on Multitasking Stress Reactivity and Mood.

Benson S, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A. Phyther Res. 2014;28(4):551-559. doi:10.1002/ptr.5029.

31. Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.

Freitas AE, Egea J, Buendia I, et al. Mol Neurobiol. 2016;53(5):3030-3045. doi:10.1007/s12035-015-9182-6.

32. Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine.

Taksande BG, Kotagale NR, Tripathi SJ, Ugale RR, Chopde CT. Neuropharmacology. 2009;57(4):415-424. doi:10.1016/j.neuropharm.2009.06.035.

33. Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial.

Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Pain Med. 2010;11(3):356-368. doi:10.1111/j.1526-4637.2010.00808.x.

34. Toxicological significance of azo dye metabolism by human intestinal microbiota.

Feng J, Cerniglia CE, Chen H. Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, AR , USA. Front Biosci (Elite Ed). 2012 Jan 1;4:568-86.

35. Artificial food dyes and attention deficit hyperactivity disorder.

Kanarek RB. Department of Psychology, Tufts University, Medford, Massachusetts, USA. Nutr Rev. 2011 Jul;69(7):385-91.

36. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives.

Nigg JT, Lewis K, Edinger T, Falk M. Oregon Health and Science University, Portland, OR, USA. J Am Acad Child Adolesc Psychiatry. 2012 Jan;51(1):86-97.e8.

37. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial.

McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO, Stevenson J. School of Psychology, Department of Child Health, University of Southampton, Southampton, UK. Lancet. 2007 Nov 3;370(9598):1560-7.

38. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.

Gao Y, Li C, Shen J, Yin H, An X, Jin H. Scientific and Technological College of Chemistry and Biology, Yantai Univ., Yantai, PR China. J Food Sci. 2011 Aug;76(6):T125-9.

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