After two years and billions of dollars of research and development, there’s still no foolproof cure for Covid.
Luckily, research shows that if you’re a healthy person under the age of sixty, your chances of being stricken, hospitalized, or killed by the disease are extremely low. Specifically, data from the CDC show that about 0.013% of 30-year olds who catch Covid have died with the disease (and not necessarily from it), whereas this number rises to 0.214% for 60-year olds and 2.836% for people aged 85 and over.
That is, if one million 30-year olds catch Covid, 130 of them will die with the disease, whereas nearly 29,000 out of a million 85-year olds would die.
What’s more, other research from the CDC shows that 95% of people who’ve died with Covid also had another serious medical condition, such as heart disease, the flu, or cancer (and on average, people who died with Covid had four additional comorbidities).
And so, many people can rightly dismiss Covid as “just another respiratory virus.”
What if they do have an underlying health condition like diabetes, heart disease, or chronic bronchitis, though?
Or, what if they’re healthy but want to make themselves as coof-proof as they possibly can?
What can and should they do?
Well, by now, scientists have collected and analyzed a terrific amount of data on Covid and have a good understanding of the key lifestyle factors that increase and decrease the risk of catching a bad case of the latest variant.
And in this article, you’ll learn the top nine.
9 Natural Ways to Reduce Your Risk of Getting (and Getting Flattened by) Covid
1. Maintain a Healthy Body Weight
Study after study has shown that being overweight or obese markedly increases your risk of severe illness or death from Covid.
For example, in one study conducted by scientists at the University of Oxford, researchers parsed the medical records of 6,910,695 people and found that those with a BMI of 23 or below had the lowest risk of admission to a hospital or intensive care or dying.
They also found that the risk of becoming seriously ill with Covid increased in lockstep with BMI. Specifically, someone with a BMI of 25 had a 10% higher risk of hospitalization and a 20% higher risk of landing up in the ICU than someone with a BMI of 23, and these numbers shot up to 35 and 70%, respectively, for someone with a BMI of 30.
Now, BMI is an imperfect barometer because lean, muscular people register inappropriately high (my BMI is about 25, for example, and I have ~40 pounds more muscle than the average person and a lot less body fat), but the point still stands:
If you’re overweight, one of the best things you can do to reduce your risk of being pasted by Covid is to trim down.
And if you’d like to learn more about how to diet properly to lose weight safely and sustainably, check out this article. And if you’d like even more specific advice about how many calories, how much of each macronutrient, and which foods you should eat to lose weight quickly, take the Legion Diet Quiz.
2. Exercise At Least 30 Minutes Every Day
It’s common knowledge that exercise boosts immune function and reduces your risk of a long list of noninfectious diseases like heart disease, cancer, and diabetes.
(In fact, studies show that strength training in particular is more effective at buttressing your body’s natural defenses than supplementing with vitamin D, which is also prudent.)
You might not know, however, that exercise also significantly reduces the risk of contagious diseases caused by viruses and bacteria such as Covid.
For instance, in one study conducted by scientists at Kaiser Permanente Medical Center, researchers found that people who were consistently inactive (did 0-to-10 minutes of exercise per week) had a three-fold increased risk of hospitalization with Covid versus people who consistently exercised at least 150 minutes per week (just 20 minutes per day) and a nearly five-fold increased risk of dying with Covid.
And what happens if you exercise more than 150 minutes per week, which is a bare minimum for maintaining health and wellbeing?
While there’s no data on how much each additional minute of exercise beyond this point bolsters your immune defenses, it’s likely that the more you exercise (up to a very high point), the lower your risk of succumbing to Covid.
For instance, the latest activity guidelines from the WHO recommend people aged 18-to-64 get at least 150-to-300 minutes of moderate physical activity or 75-to-150 minutes of vigorous physical activity plus at least two strength training sessions per week. And again, this is considered a minimum threshold for staving off disease, not necessarily an ideal dose for optimizing health, mood, vitality, physical performance, and body composition.
(And if you’d like to learn more about how and how much you should exercise to accomplish these goals, check out my books for men and women, Bigger Leaner Stronger and Thinner Leaner Stronger.)
3. Get Enough Sleep
Chronic sleep deprivation is devastating to our health and wellbeing, so it’s no surprise that studies routinely show that people who sleep more are at a lower risk of ill health from immune-related disease like Covid than people who sleep less.
Although the “optimal” sleep duration for each person is largely determined by their genetics, a good rule of thumb for most of us is to aim for 7-to-9 hours of sleep per night.
And if you find it difficult to drop off in the evening, here are several ways to improve your “sleep hygiene”:
- Avoid coffee, nicotine, alcohol, and other stimulants four-to-six hours before you go to bed (or longer if necessary).
- Make your bedroom quiet, cool, and dark.
- Don’t eat or drink too much before bed.
- Create a relaxing pre-bed routine that might include things like reading, stretching, or bathing.
- If you can’t sleep, get out of bed and do something quiet and relaxing until you feel the urge to fall asleep, like reading, listening to music, or solving puzzles. Once you feel sleepy, go back to bed.
- Go to bed at the same time every night.
- Only use your bedroom for two things: sleep and sex.
4. Drink Less Alcohol
One study conducted by scientists at Shenzhen Mental Health Centre made headlines recently when it suggested that consuming red and white wine and champagne reduces your risk of dying from Covid, while consuming beer, cider, and spirits increases your risk.
Winos rejoiced, but what the scientists and media outlets failed to mention was that any link between wine drinking and reduced risk from Covid was correlative, not causative (which, by the way, is almost always the case when you see paradoxical outcomes like this).
That is, the researchers noticed that people who drank red and white wine and champagne tended to have a lower risk of dying from Covid, but that doesn’t mean the plonk deserves credit.
In reality, research shows that heavy drinking inhibits immune function, whereas moderate drinking isn’t likely to help or hurt immune function.
This is particularly apropos to Covid, as the lockdowns have caused many people to drink more alcohol to cope with the fear, loneliness, and depression, and those who increased their drinking the most tended to experience rougher Covid symptoms.
Thus, if you already drink moderately, giving up alcohol entirely is unlikely to reduce your risk of getting sick. That said, if you’re often teetering between “moderate” and “excessive” alcohol intake or are an unabashed boozer, cutting back will reduce your chances of getting shellacked by Covid.
5. Chill Out
Studies show that stress—and indeed loneliness—can suppress immune function and make you more susceptible to infection and illness.
The best way to counteract stress is to find ways to relax, and here are a few evidence-based strategies to help quiet the noise and cool your jets:
- Change your perspective on stress: Research shows that our perception of stress as harmful is what really gives it teeth. That is, it’s possible that getting overly stressed about stress is what makes it harmful.
Studies show that we can consciously reappraise stressful situations—choose to look at them differently—and thereby deprive them of their destructive power.
A frustrating situation doesn’t have to be an excuse to rip your hair out. Instead, it can be viewed as an opportunity to exercise a virtue like patience or tolerance. Or an opportunity to learn what doesn’t work. Or to learn that you’re tougher than you thought.
- Listen to classical music: Next time you’re stressed, put on some slow, quiet classical music and before long you’ll be nestled in its soothing embrace.
Mozart can do more than just chill you out, too. Studies show that classical music sharpens your mind and engages your emotions and lowers blood pressure, lessens physical pain and depression, and helps you sleep better.
- Consume less media: Research shows that exposing yourself to a constant barrage of bad news, fearmongering, and morbid reminders of your mortality increases stress levels. (Well, I declare!)
While the media has always spotlighted tragedy and turmoil (“if it bleeds, it leads”), this bias has now reached gargantuan proportions. For instance, economists from the National Bureau of Economic Research found that 87% of US news coverage on Covid has been negative, whereas only 54% of news coverage was negative in most other countries and 65% in scientific journals. Basically, most US news outlets embellish bad news (“cases are rising!”) and bury the good (“deaths and hospitalizations are falling”) to give the gloomiest impression possible.
If you don’t want to swear off media altogether, limiting yourself to one 15-to-20 minute bout of news browsing per day is a sensible compromise.
- Spend less time with tech: Research shows that the more people use and feel tied to their computers and cell phones, the more stressed they feel. In fact, overuse of technology has even been linked with various symptoms of poor mental health like depression.
Scientists aren’t certain as to exactly what causes this, but the relationship is unmistakable. The more time we spend with our devices, the worse our mental state becomes.
- Spend more time with people: Spending time with people, especially your nearest and dearest, is one of the best ways to settle your stress and extinguish your anxiety. So make seeing people in the flesh a priority, even if it’s a hassle.
6. Quit Smoking
Given the carnage that smoking causes on your respiratory health and immune function, it figures that many studies show a consistent, positive association between smoking and the risk of Covid-related death.
The good news is it doesn’t take long for cardiovascular health and respiratory function to begin improving once you quit. And if you’ve tried and failed in the past, here are three strategies that help you kick the habit:
- Using nicotine replacement therapy (NRT)
- Taking non-nicotine medications like varenicline or bupropion
- Seeking behavioral support like cognitive behavioral therapy
7. Eat a Healthy Diet
When your body gets infected by a virus such as SARS-CoV-2, your immune system creates a cascade of proteins, immune cells, and molecules such as lipid-derived mediators that rush to fight the infection.
To organize this molecular assault, your body uses the nutrients supplied by the food you eat as raw materials. And multiple studies show that the fewer vitamins, minerals, and nutrients you eat, the fewer there are available to mount a robust immune response, and the more likely you are to become severely ill.
Therefore, an easy way to shore up your body’s defenses is to eat a healthy diet, which includes . . .
- The right number of calories and enough protein, carbohydrates, and fat to maintain a healthy body composition
- Enough vitamins, minerals, fiber, and other nutrients to function well without the need for supplementation
- Enough water to stay hydrated
And while there are no hard and fast rules about how much of each food or food group to eat or not eat, a healthy diet also includes an abundance of whole, nutritious, relatively unprocessed foods like fruits, vegetables, whole grains, lean meats, fish, dairy, pulses, nuts, seeds, legumes, and plant oils.
A good rule of thumb is to shoot for at least 2-to-3 servings of fruit per day and 3-to-5 servings of vegetables per day, with additional whole grains, legumes, nuts and seeds based on your preferences and calorie needs.
8. Spend Time Outdoors
Just a few years ago, vitamin D was known as the “bone vitamin,” and even today many physicians still believe it’s mainly needed for bone health.
While this is true, having insufficient vitamin D levels also increases your risk of many types of disease, including heart disease, stroke, some cancers, type 1 diabetes, multiple sclerosis, tuberculosis, and even Covid.
For example, in one study conducted by scientists at Galilee Medical Center, researchers found that people with a vitamin D deficiency were 14 times more likely to become severely ill with Covid than people who had adequate levels of vitamin D.
What’s more, the researchers found that the mortality rate among people who had sufficient vitamin D levels was 2.3%, but this rose to 25.6% for people with a vitamin D deficiency.
Aside from supplementing (more on this next), one of the best ways to keep D levels topped off is spending time outdoors in the sun.
A good place to start is spending 30 minutes per day outside. This is enough to produce a little extra vitamin D and lower your risk of diabetes, cardiovascular disease, and poor mental health. That said, if you live in cold, northerly climes or you’re bundled up against the cold (and shielded against the sun), supplementation is the answer.
9. Take the Right Supplements
Unfortunately, no pill, powder, or potion (or injection) will bulletproof you against Covid.
There are a few supplements that appear to lessen the severity of Covid for some people, though, and these are . . .
- Omega-3 fatty acids: Research shows that fish oil reduces systemic inflammation and thus may help to minimize the likelihood of ill health and death from Covid. If you want a high-potency, molecularly distilled fish oil with added vitamin E, try Triton.
- Vitamin C and D and selenium: Studies show that maintaining high levels of vitamin C and D and selenium lowers your risk of becoming severely ill with Covid. If you want a multivitamin that contains clinically effective doses of vitamin C and D and selenium, as well as 28 other ingredients designed to enhance your health and mood and reduce stress, fatigue, and anxiety, try Triumph.
- L-citrulline: L-citrulline increases the production of a gas known as nitric oxide that widens blood vessels and improves blood flow. While the research is very much in its infancy, early signs are that L-citrulline may help to lessen the severity of Covid symptoms such as breathlessness and chest pain. If you want a 100% natural L-citrulline supplement that also contains five other ingredients designed to enhance energy, mood, and focus, increase strength and endurance, and reduce fatigue, try Pulse.
- Quercetin: Quercetin is a natural pigment found in fruits and vegetables that acts as an anti-inflammatory, antioxidant, and analgesic in the body. Some studies suggest quercetin may slow the spread of SARS-CoV-2 in the body by preventing it from infecting new cells, which may decrease symptom severity and length of infection.
- Zinc: Due to its anti-inflammatory, antioxidant, and antiviral properties, several studies have tentatively suggested that zinc may provide an additional “shield” against infection with and illness from Covid.
- Melatonin: Research shows that the antioxidant, anti-inflammatory, and immunomodulatory effects of melatonin may reduce the severity of Covid symptoms when used as an early treatment.
- Nigella Sativa: Preliminary research shows that nigella sativa, or ”black cumin seed,” may make recovery from Covid quicker in people with mild infection.
- Antiviral mouthwash: Studies show that rinsing your mouth with antiviral mouthwashes containing chlorhexidine, povidone-iodine, or cetylpyridinium chloride may reduce the SARS-CoV-2 viral load in saliva, which may reduce your risk of spreading the virus and speed up your recovery time.
Scientific References +
- Tiruneh, S. A., Tesema, Z. T., Azanaw, M. M., & Angaw, D. A. (2021). The effect of age on the incidence of COVID-19 complications: a systematic review and meta-analysis. Systematic Reviews, 10(1), 1–9. https://doi.org/10.1186/S13643-021-01636-2/TABLES/3
- Ioannidis, J. P. A., Axfors, C., & Contopoulos-Ioannidis, D. G. (2020). Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters. Environmental Research, 188, 109890. https://doi.org/10.1016/J.ENVRES.2020.109890
- Bhaskaran, K., Bacon, S., Evans, S. J., Bates, C. J., Rentsch, C. T., MacKenna, B., Tomlinson, L., Walker, A. J., Schultze, A., Morton, C. E., Grint, D., Mehrkar, A., Eggo, R. M., Inglesby, P., Douglas, I. J., McDonald, H. I., Cockburn, J., Williamson, E. J., Evans, D., … Goldacre, B. (2021). Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. The Lancet Regional Health - Europe, 6. https://doi.org/10.1016/J.LANEPE.2021.100109/ATTACHMENT/E48C5426-B65E-4506-BE11-6D3190B0D095/MMC1.PDF
- Ahmed, S. I., Hasan, S. M. T., & Ahmed, T. (2020). Obesity is a potential risk factor for covid-19 associated morbidity and mortality in urban Bangladesh. BMJ (Clinical Research Ed.), 370. https://doi.org/10.1136/BMJ.M2811
- Zhang, X., Lewis, A. M., Moley, J. R., & Brestoff, J. R. (2021). A systematic review and meta-analysis of obesity and COVID-19 outcomes. Scientific Reports 2021 11:1, 11(1), 1–11. https://doi.org/10.1038/s41598-021-86694-1
- Hamer, M., Kivimäki, M., Gale, C. R., & Batty, G. D. (2020). Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: A community-based cohort study of 387,109 adults in UK. Brain, Behavior, and Immunity, 87, 184–187. https://doi.org/10.1016/J.BBI.2020.05.059
- Popkin, B. M., Du, S., Green, W. D., Beck, M. A., Algaith, T., Herbst, C. H., Alsukait, R. F., Alluhidan, M., Alazemi, N., & Shekar, M. (2020). Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obesity Reviews, 21(11), e13128. https://doi.org/10.1111/OBR.13128
- Demeulemeester, F., de Punder, K., van Heijningen, M., & van Doesburg, F. (2021). Obesity as a Risk Factor for Severe COVID-19 and Complications: A Review. Cells, 10(4). https://doi.org/10.3390/CELLS10040933
- Gao, M., Piernas, C., Astbury, N. M., Hippisley-Cox, J., O’Rahilly, S., Aveyard, P., & Jebb, S. A. (2021). Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. The Lancet Diabetes and Endocrinology, 9(6), 350–359. https://doi.org/10.1016/S2213-8587(21)00089-9/ATTACHMENT/88CB76D8-D2D5-4B73-9A05-FFFEFAD4DE8D/MMC1.PDF
- Neil P Walsh 1, M. G. D. B. P. D. C. N. F. S. D. R. J. S. S. J. O. S. B. A. K. (n.d.). Position statement. Part two: Maintaining immune health - PubMed. Retrieved February 23, 2022, from https://pubmed.ncbi.nlm.nih.gov/21446353/
- Neil P Walsh 1, M. G. R. J. S. M. G. J. A. W. N. C. B. M. F. C. G. B. K. P. L. H.-G. C. J. R. H. N. A. A. P. S. (n.d.). Position statement. Part one: Immune function and exercise - PubMed. Retrieved February 23, 2022, from https://pubmed.ncbi.nlm.nih.gov/21446352/
- Nieman, D. C., & Wentz, L. M. (2019). The compelling link between physical activity and the body’s defense system. Journal of Sport and Health Science, 8(3), 201–217. https://doi.org/10.1016/J.JSHS.2018.09.009
- Warburton, D. E. R., & Bredin, S. S. D. (2017). Health benefits of physical activity: a systematic review of current systematic reviews. Current Opinion in Cardiology, 32(5), 541–556. https://doi.org/10.1097/HCO.0000000000000437
- Martens, P. J., Gysemans, C., Verstuyf, A., & Mathieu, C. (2020). Vitamin D’s Effect on Immune Function. Nutrients, 12(5). https://doi.org/10.3390/NU12051248
- Pape, K., Ryttergaard, L., Rotevatn, T. A., Nielsen, B. J., Torp-Pedersen, C., Overgaard, C., & BØggild, H. (2016). Leisure-Time Physical Activity and the Risk of Suspected Bacterial Infections. Medicine and Science in Sports and Exercise, 48(9), 1737–1744. https://doi.org/10.1249/MSS.0000000000000953
- Leveille, S. G., Gray, S., Lacroix, A. Z., Ferrucci, L., Black, D. J., & Guralnik, J. M. (2000). Physical inactivity and smoking increase risk for serious infections in older women. Journal of the American Geriatrics Society, 48(12), 1582–1588. https://doi.org/10.1111/J.1532-5415.2000.TB03867.X
- Romaniszyn, D., Pobiega, M., Wójkowska-Mach, J., Chmielarczyk, A., Gryglewska, B., Adamski, P., Heczko, P. B., Ochońska, D., & Bulanda, M. (2014). The general status of patients and limited physical activity as risk factors of Methicillin-resistant Staphylococcus aureus occurrence in long-term care facilities residents in Krakow, Poland. BMC Infectious Diseases, 14(1), 271. https://doi.org/10.1186/1471-2334-14-271
- Baik, I., Curhan, G. C., Rimm, E. B., Bendich, A., Willett, W. C., & Fawzi, W. W. (2000). A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Archives of Internal Medicine, 160(20), 3082–3088. https://doi.org/10.1001/ARCHINTE.160.20.3082
- Arazi, H., Falahati, A., & Suzuki, K. (2021). Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects. Frontiers in Physiology, 12, 1936. https://doi.org/10.3389/FPHYS.2021.747200/BIBTEX
- Kaur, H., Singh, T., Arya, Y. K., & Mittal, S. (2020). Physical Fitness and Exercise During the COVID-19 Pandemic: A Qualitative Enquiry. Frontiers in Psychology, 11. https://doi.org/10.3389/FPSYG.2020.590172
- Seman, S., Dražilov, S. S., Ilić, V., Tešić, M., Stojiljković, S., Arena, R., & Popović, D. (2021). Physical activity and exercise as an essential medical strategy for the COVID-19 pandemic and beyond. Experimental Biology and Medicine, 246(21), 2324–2331. https://doi.org/10.1177/15353702211028543
- Sallis, R., Young, D. R., Tartof, S. Y., Sallis, J. F., Sall, J., Li, Q., Smith, G. N., & Cohen, D. A. (2021). Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. British Journal of Sports Medicine, 55(19), 1099–1105. https://doi.org/10.1136/BJSPORTS-2021-104080
- Lee, S. W., Lee, J., Moon, S. Y., Jin, H. Y., Yang, J. M., Ogino, S., Song, M., Hong, S. H., Abou Ghayda, R., Kronbichler, A., Koyanagi, A., Jacob, L., Dragioti, E., Smith, L., Giovannucci, E., Lee, I. M., Lee, D. H., Lee, K. H., Shin, Y. H., … Yon, D. K. (2021). Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study. British Journal of Sports Medicine. https://doi.org/10.1136/BJSPORTS-2021-104203
- Garbarino, S., Lanteri, P., Bragazzi, N. L., Magnavita, N., & Scoditti, E. (2021). Role of sleep deprivation in immune-related disease risk and outcomes. Communications Biology 2021 4:1, 4(1), 1–17. https://doi.org/10.1038/s42003-021-02825-4
- Kim, H., Hegde, S., Lafiura, C., Raghavan, M., Luong, E., Cheng, S., Rebholz, C. M., & Seidelmann, S. B. (2021). COVID-19 illness in relation to sleep and burnout. BMJ Nutrition, Prevention & Health, 4(1), 132–139. https://doi.org/10.1136/BMJNPH-2021-000228
- De Gennaro, L., Marzano, C., Fratello, F., Moroni, F., Pellicciari, M. C., Ferlazzo, F., Costa, S., Couyoumdjian, A., Curcio, G., Sforza, E., Malafosse, A., Finelli, L. A., Pasqualetti, P., Ferrara, M., Bertini, M., & Rossini, P. M. (2008). The electroencephalographic fingerprint of sleep is genetically determined: a twin study. Annals of Neurology, 64(4), 455–460. https://doi.org/10.1002/ANA.21434
- Ambrosius, U., Lietzenmaier, S., Wehrle, R., Wichniak, A., Kalus, S., Winkelmann, J., Bettecken, T., Holsboer, F., Yassouridis, A., & Friess, E. (2008). Heritability of sleep electroencephalogram. Biological Psychiatry, 64(4), 344–348. https://doi.org/10.1016/J.BIOPSYCH.2008.03.002
- Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., Malhotra, R. K., Martin, J. L., Patel, S. R., Quan, S. F., Tasali, E., Twery, M., Croft, J. B., Maher, E., Barrett, J. A., … Heald, J. L. (2015). Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep, 38(6), 843. https://doi.org/10.5665/SLEEP.4716
- Hirshkowitz, M., Whiton, K., Albert, S. M., Alessi, C., Bruni, O., DonCarlos, L., Hazen, N., Herman, J., Katz, E. S., Kheirandish-Gozal, L., Neubauer, D. N., O’Donnell, A. E., Ohayon, M., Peever, J., Rawding, R., Sachdeva, R. C., Setters, B., Vitiello, M. V., Ware, J. C., & Adams Hillard, P. J. (2015). National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health, 1(1), 40–43. https://doi.org/10.1016/J.SLEH.2014.12.010
- Stepanski, E. J., & Wyatt, J. K. (2003). Use of sleep hygiene in the treatment of insomnia. Sleep Medicine Reviews, 7(3), 215–225. https://doi.org/10.1053/SMRV.2001.0246
- Jaehne, A., Loessl, B., Bárkai, Z., Riemann, D., & Hornyak, M. (2009). Effects of nicotine on sleep during consumption, withdrawal and replacement therapy. Sleep Medicine Reviews, 13(5), 363–377. https://doi.org/10.1016/J.SMRV.2008.12.003
- Ebrahim, I. O., Shapiro, C. M., Williams, A. J., & Fenwick, P. B. (2013). Alcohol and sleep I: effects on normal sleep. Alcoholism, Clinical and Experimental Research, 37(4), 539` – 549. https://doi.org/10.1111/ACER.12006
- Stansfeld, S., Hygge, S., Clark, C., & Alfred, T. (2010). Night time aircraft noise exposure and children’s cognitive performance. Noise and Health, 12(49), 255–262. https://doi.org/10.4103/1463-1741.70504
- Cho, C. H., Yoon, H. K., Kang, S. G., Kim, L., Lee, E. Il, & Lee, H. J. (2018). Impact of Exposure to Dim Light at Night on Sleep in Female and Comparison with Male Subjects. Psychiatry Investigation, 15(5), 520. https://doi.org/10.30773/PI.2018.03.17
- Crispim, C. A., Zimberg, I. Z., Gomes Dos Reis, B., Diniz, R. M., Tufik, S., & Túlio De Mello, M. (2011). Relationship between Food Intake and Sleep Pattern in Healthy Individuals. Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine, 7(6), 659. https://doi.org/10.5664/JCSM.1476
- Stepanski, E. J., & Wyatt, J. K. (2003). Use of sleep hygiene in the treatment of insomnia. Sleep Medicine Reviews, 7(3), 215–225. https://doi.org/10.1053/SMRV.2001.0246
- Espie, C. A., Inglis, S. J., Tessier, S., & Harvey, L. (2001). The clinical effectiveness of cognitive behaviour therapy for chronic insomnia: implementation and evaluation of a sleep clinic in general medical practice. Behaviour Research and Therapy, 39(1), 45–60. https://doi.org/10.1016/S0005-7967(99)00157-6
- Dijk, D. J., & Lockley, S. W. (2002). Integration of human sleep-wake regulation and circadian rhythmicity. Journal of Applied Physiology (Bethesda, Md. : 1985), 92(2), 852–862. https://doi.org/10.1152/JAPPLPHYSIOL.00924.2001
- Jefferson, C. D., Drake, C. L., Scofield, H. M., Myers, E., McClure, T., Roehrs, T., & Roth, T. (2005). Sleep hygiene practices in a population-based sample of insomniacs. Sleep, 28(5), 611–615. https://doi.org/10.1093/SLEEP/28.5.611
- Buysse, D. J., Cheng, Y., Germain, A., Moul, D. E., Franzen, P. L., Fletcher, M., & Monk, T. H. (2010). Night-to-night sleep variability in older adults with and without chronic insomnia. Sleep Medicine, 11(1), 56–64. https://doi.org/10.1016/J.SLEEP.2009.02.010
- Lastella, M., O’Mullan, C., Paterson, J. L., & Reynolds, A. C. (2019). Sex and Sleep: Perceptions of Sex as a Sleep Promoting Behavior in the General Adult Population. Frontiers in Public Health, 7(MAR), 33. https://doi.org/10.3389/FPUBH.2019.00033
- Dai, X. J., Tan, L., Ren, L., Shao, Y., Tao, W., & Wang, Y. (2022). COVID-19 Risk Appears to Vary Across Different Alcoholic Beverages. Frontiers in Nutrition, 8. https://doi.org/10.3389/FNUT.2021.772700
- Barr, T., Helms, C., Grant, K., & Messaoudi, I. (2016). Opposing Effects of Alcohol on the Immune System. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 65, 242. https://doi.org/10.1016/J.PNPBP.2015.09.001
- Alcohol and the Immune System. (n.d.). Retrieved February 23, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590612/
- Watzl, B., Bub, A., Pretzer, G., Roser, S., Barth, S. W., & Rechkemmer, G. (2004). Daily moderate amounts of red wine or alcohol have no effect on the immune system of healthy men. European Journal of Clinical Nutrition, 58(1), 40–45. https://doi.org/10.1038/SJ.EJCN.1601742
- Watzl, B., Bub, A., Briviba, K., & Rechkemmer, G. (2002). Acute intake of moderate amounts of red wine or alcohol has no effect on the immune system of healthy men. European Journal of Nutrition, 41(6), 264–270. https://doi.org/10.1007/S00394-002-0384-0
- Killgore, W. D. S., Cloonan, S. A., Taylor, E. C., Lucas, D. A., & Dailey, N. S. (2021). Alcohol dependence during COVID-19 lockdowns. Psychiatry Research, 296, 113676. https://doi.org/10.1016/J.PSYCHRES.2020.113676
- Steffen, J., Schlichtiger, J., Huber, B. C., & Brunner, S. (2021). Altered alcohol consumption during COVID-19 pandemic lockdown. Nutrition Journal, 20(1), 1–6. https://doi.org/10.1186/S12937-021-00699-0/TABLES/4
- Guignard, R., Andler, R., Quatremère, G., Pasquereau, A., du Roscoät, E., Arwidson, P., Berlin, I., & Nguyen-Thanh, V. (2021). Changes in smoking and alcohol consumption during COVID-19-related lockdown: a cross-sectional study in France. European Journal of Public Health, 31(5), 1076–1083. https://doi.org/10.1093/EURPUB/CKAB054
- Merlo, A., Hendriksen, P. A., Severeijns, N. R., Garssen, J., Bruce, G., & Verster, J. C. (2021). Alcohol Consumption Patterns during COVID-19 Lockdown and Their Relationship with Perceived Immune Fitness and Reported COVID-19 Symptoms. Healthcare 2021, Vol. 9, Page 1039, 9(8), 1039. https://doi.org/10.3390/HEALTHCARE9081039
- Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proceedings of the National Academy of Sciences of the United States of America, 109(16), 5995–5999. https://doi.org/10.1073/PNAS.1118355109
- D’Acquisto, F., & Hamilton, A. (2020). Cardiovascular and immunological implications of social distancing in the context of COVID-19. Cardiovascular Research, 116(10), e129. https://doi.org/10.1093/CVR/CVAA167
- Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002). Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology. Annual Review of Psychology, 53, 83–107. https://doi.org/10.1146/ANNUREV.PSYCH.53.100901.135217
- Keller, A., Litzelman, K., Wisk, L. E., Maddox, T., Cheng, E. R., Creswell, P. D., & Witt, W. P. (2012). Does the perception that stress affects health matter? The association with health and mortality. Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association, 31(5), 677–684. https://doi.org/10.1037/A0026743
- Troy, A. S., Wilhelm, F. H., Shallcross, A. J., & Mauss, I. B. (2010). Seeing the silver lining: cognitive reappraisal ability moderates the relationship between stress and depressive symptoms. Emotion (Washington, D.C.), 10(6), 783–795. https://doi.org/10.1037/A0020262
- Jenkins, J. S. (2001). The Mozart effect. Journal of the Royal Society of Medicine, 94(4), 170. https://doi.org/10.1177/014107680109400404
- Jensen, K. L. (2001). The effects of selected classical music on self-disclosure. Journal of Music Therapy, 38(1), 2–27. https://doi.org/10.1093/JMT/38.1.2
- Chafin, S., Roy, M., Gerin, W., & Christenfeld, N. (2004). Music can facilitate blood pressure recovery from stress. British Journal of Health Psychology, 9(Pt 3), 393–403. https://doi.org/10.1348/1359107041557020
- Siedliecki, S. L., & Good, M. (2006). Effect of music on power, pain, depression and disability. Journal of Advanced Nursing, 54(5), 553–562. https://doi.org/10.1111/J.1365-2648.2006.03860.X
- Hanser, S. B., & Thompson, L. W. (1994). Effects of a music therapy strategy on depressed older adults. Journal of Gerontology, 49(6). https://doi.org/10.1093/GERONJ/49.6.P265
- Scheufele, P. M. (2000). Effects of Progressive Relaxation and Classical Music on Measurements of Attention, Relaxation, and Stress Responses. Journal of Behavioral Medicine 2000 23:2, 23(2), 207–228. https://doi.org/10.1023/A:1005542121935
- Boukes, M., & Vliegenthart, R. (2017). News consumption and its unpleasant side effect: Studying the effect of hard and soft news exposure on mental well-being over time. Journal of Media Psychology, 29(3), 137–147. https://doi.org/10.1027/1864-1105/A000224
- de Hoog, N., & Verboon, P. (2020). Is the news making us unhappy? The influence of daily news exposure on emotional states. British Journal of Psychology (London, England : 1953), 111(2), 157–173. https://doi.org/10.1111/BJOP.12389
- Thomée, S., Härenstam, A., & Hagberg, M. (2011). Mobile phone use and stress, sleep disturbances, and symptoms of depression among young adults - A prospective cohort study. BMC Public Health, 11(1), 1–11. https://doi.org/10.1186/1471-2458-11-66/TABLES/4
- Lepp, A., Barkley, J. E., & Karpinski, A. C. (2014). The relationship between cell phone use, academic performance, anxiety, and Satisfaction with Life in college students. Computers in Human Behavior, 31(1), 343–350. https://doi.org/10.1016/J.CHB.2013.10.049
- van Harmelen, A. L., Gibson, J. L., St Clair, M. C., Owens, M., Brodbeck, J., Dunn, V., Lewis, G., Croudace, T., Jones, P. B., Kievit, R. A., & Goodyer, I. M. (2016). Friendships and Family Support Reduce Subsequent Depressive Symptoms in At-Risk Adolescents. PLOS ONE, 11(5), e0153715. https://doi.org/10.1371/JOURNAL.PONE.0153715
- Ozbay, F., Johnson, D. C., Dimoulas, E., Morgan, C. A., III, Charney, D., & Southwick, S. (2007). Social Support and Resilience to Stress: From Neurobiology to Clinical Practice. Psychiatry (Edgmont), 4(5), 35. /pmc/articles/PMC2921311/
- Sales, M. P. U., de Araújo, A. J., Miguel Chatkin, J., de Godoy, I., Pereira, L. F. F., Castellano, M. V. C. de O., Tanni, S. E., de Almeida, A. Á., Chatkin, G., Côrrea da Silva, L. C., Gonçalves, C. M. C., Botelho, C., Santos, U. P., Viegas, C. A. de A., Sestelo, M. R., Meireles, R. H. S., Correa, P. C. R. P., de Oliveira, M. E. M., Reichert, J., … da Silva, C. A. R. (2019). Update on the approach to smoking in patients with respiratory diseases. Jornal Brasileiro de Pneumologia, 45(3). https://doi.org/10.1590/1806-3713/E20180314
- Grumelli, S., Corry, D. B., Song, L. Z., Song, L., Green, L., Huh, J., Hacken, J., Espada, R., Bag, R., Lewis, D. E., & Kheradmand, F. (2004). An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Medicine, 1, 075–083. https://doi.org/10.1371/JOURNAL.PMED.0010008
- Qiu, F., Liang, C. L., Liu, H., Zeng, Y. Q., Hou, S., Huang, S., Lai, X., & Dai, Z. (2017). Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Oncotarget, 8(1), 268. https://doi.org/10.18632/ONCOTARGET.13613
- Strzelak, A., Ratajczak, A., Adamiec, A., & Feleszko, W. (2018). Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review. International Journal of Environmental Research and Public Health, 15(5). https://doi.org/10.3390/IJERPH15051033
- Haddad, C., Malhab, S. B., Sacre, H., & Salameh, P. (2021). Smoking and COVID-19: A Scoping Review. Tobacco Use Insights, 14, 1179173X2199461. https://doi.org/10.1177/1179173X21994612
- Clift, A. K., von Ende, A., Tan, P. S., Sallis, H. M., Lindson, N., Coupland, C. A. C., Munafò, M. R., Aveyard, P., Hippisley-Cox, J., & Hopewell, J. C. (2022). Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort. Thorax, 77(1), 65–73. https://doi.org/10.1136/THORAXJNL-2021-217080
- He, Y., Sun, J., Ding, X., & Wang, Q. (2021). Mechanisms in Which Smoking Increases the Risk of COVID-19 Infection: A Narrative Review. Iranian Journal of Public Health, 50(3), 431. https://doi.org/10.18502/IJPH.V50I3.5582
- Derella, C. C., Tingen, M. S., Blanks, A., Sojourner, S. J., Tucker, M. A., Thomas, J., & Harris, R. A. (2021). Smoking cessation reduces systemic inflammation and circulating endothelin-1. Scientific Reports 2021 11:1, 11(1), 1–8. https://doi.org/10.1038/s41598-021-03476-5
- Willemse, B. W. M., Postma, D. S., Timens, W., & ten Hacken, N. H. T. (2004). The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. European Respiratory Journal, 23(3), 464–476. https://doi.org/10.1183/09031936.04.00012704
- Rigotti, N. A. (2012). Strategies to Help a Smoker Who Is Struggling to Quit. JAMA, 308(15), 1573–1580. https://doi.org/10.1001/JAMA.2012.13043
- McDonough, M. (2015). Update on medicines for smoking cessation. Australian Prescriber, 38(4), 106. https://doi.org/10.18773/AUSTPRESCR.2015.038
- Galanti, L. M. (2008). Tobacco smoking cessation management: integrating varenicline in current practice. Vascular Health and Risk Management, 4(4), 837. https://doi.org/10.2147/VHRM.S3250
- Salisbury-Afshar, E. (2018). Individual behavioral counseling for smoking cessation. American Family Physician, 98(1), 21–22. https://doi.org/10.1002/14651858.CD001292.PUB2/INFORMATION/EN
- Stead, L. F., Koilpillai, P., & Lancaster, T. (2015). Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation. Cochrane Database of Systematic Reviews, 2015(10). https://doi.org/10.1002/14651858.CD009670.PUB3/MEDIA/CDSR/CD009670/REL0003/CD009670/IMAGE_N/NCD009670-CMP-002-02.PNG
- Killen, J. D., Fortmann, S. P., Schatzberg, A. F., Arredondo, C., Murphy, G., Hayward, C., Celio, M., Cromp, D. A., Fong, D., & Pandurangi, M. (2008). Extended cognitive behavior therapy for cigarette smoking cessation. Addiction (Abingdon, England), 103(8), 1381. https://doi.org/10.1111/J.1360-0443.2008.02273.X
- Martínez-Vispo, C., Rodríguez-Cano, R., López-Durán, A., Senra, C., Del Río, E. F., & Becoña, E. (2019). Cognitive-behavioral treatment with behavioral activation for smoking cessation: Randomized controlled trial. PLoS ONE, 14(4). https://doi.org/10.1371/JOURNAL.PONE.0214252
- Vinci, C. (2020). Cognitive Behavioral and Mindfulness-Based Interventions for Smoking Cessation: a Review of the Recent Literature. Current Oncology Reports, 22(6), 58. https://doi.org/10.1007/S11912-020-00915-W
- Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019). Nutritional modulation of immune function: Analysis of evidence, mechanisms, and clinical relevance. Frontiers in Immunology, 10(JAN), 3160. https://doi.org/10.3389/FIMMU.2018.03160/BIBTEX
- Calder, P. C. (2013). Feeding the immune system. Proceedings of the Nutrition Society, 72(3), 299–309. https://doi.org/10.1017/S0029665113001286
- Childs, C. E., Calder, P. C., & Miles, E. A. (2019). Diet and Immune Function. Nutrients, 11(8). https://doi.org/10.3390/NU11081933
- Gombart, A. F., Pierre, A., & Maggini, S. (2020). A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection. Nutrients 2020, Vol. 12, Page 236, 12(1), 236. https://doi.org/10.3390/NU12010236
- Calder, P. C. (2021). Nutrition and immunity: lessons for COVID-19. European Journal of Clinical Nutrition 2021 75:9, 75(9), 1309–1318. https://doi.org/10.1038/s41430-021-00949-8
- Butler, M. J., & Barrientos, R. M. (2020). The impact of nutrition on COVID-19 susceptibility and long-term consequences. Brain, Behavior, and Immunity, 87, 53–54. https://doi.org/10.1016/J.BBI.2020.04.040
- Aman, F., & Masood, S. (2020). How Nutrition can help to fight against COVID-19 Pandemic. Pakistan Journal of Medical Sciences, 36(COVID19-S4), S121. https://doi.org/10.12669/PJMS.36.COVID19-S4.2776
- Merino, J., Joshi, A. D., Nguyen, L. H., Leeming, E. R., Mazidi, M., Drew, D. A., Gibson, R., Graham, M. S., Lo, C. H., Capdevila, J., Murray, B., Hu, C., Selvachandran, S., Hammers, A., Bhupathiraju, S. N., Sharma, S. V., Sudre, C., Astley, C. M., Chavarro, J. E., … Chan, A. T. (2021). Diet quality and risk and severity of COVID-19: a prospective cohort study. Gut, 70(11), 2096–2104. https://doi.org/10.1136/GUTJNL-2021-325353
- Dawson-Hughes, B., Mithal, A., Bonjour, J. P., Boonen, S., Burckhardt, P., Fuleihan, G. E. H., Josse, R. G., Lips, P., Morales-Torres, J., & Yoshimura, N. (2010). IOF position statement: vitamin D recommendations for older adults. Osteoporosis International : A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 21(7), 1151–1154. https://doi.org/10.1007/S00198-010-1285-3
- Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K., Benjamin, E. J., D’Agostino, R. B., Wolf, M., & Vasan, R. S. (2008). Vitamin D deficiency and risk of cardiovascular disease. Circulation, 117(4), 503–511. https://doi.org/10.1161/CIRCULATIONAHA.107.706127
- Pilz, S., Dobnig, H., Fischer, J. E., Wellnitz, B., Seelhorst, U., Boehm, B. O., & März, W. (2008). Low vitamin d levels predict stroke in patients referred to coronary angiography. Stroke, 39(9), 2611–2613. https://doi.org/10.1161/STROKEAHA.107.513655
- Giovannucci, E. (2007). Epidemiological evidence for vitamin D and colorectal cancer. Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research, 22 Suppl 2(SUPPL. 2). https://doi.org/10.1359/JBMR.07S206
- Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M. R., & Virtanen, S. M. (2001). Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet (London, England), 358(9292), 1500–1503. https://doi.org/10.1016/S0140-6736(01)06580-1
- Munger, K. L., Levin, L. I., Hollis, B. W., Howard, N. S., & Ascherio, A. (2006). Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA, 296(23), 2832–2838. https://doi.org/10.1001/JAMA.296.23.2832
- Nnoaham, K. E., & Clarke, A. (2008). Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. International Journal of Epidemiology, 37(1), 113–119. https://doi.org/10.1093/IJE/DYM247
- Chiodini, I., Gatti, D., Soranna, D., Merlotti, D., Mingiano, C., Fassio, A., Adami, G., Falchetti, A., Eller-Vainicher, C., Rossini, M., Persani, L., Zambon, A., & Gennari, L. (2021). Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Frontiers in Public Health, 9, 1968. https://doi.org/10.3389/FPUBH.2021.736665/BIBTEX
- Kenneth Weir, E., Thenappan, T., Bhargava, M., & Chen, Y. (2020). Does vitamin D deficiency increase the severity of COVID-19? Clinical Medicine, 20(4), e107. https://doi.org/10.7861/CLINMED.2020-0301
- Teshome, A., Adane, A., Girma, B., & Mekonnen, Z. A. (2021). The Impact of Vitamin D Level on COVID-19 Infection: Systematic Review and Meta-Analysis. Frontiers in Public Health, 9, 624559. https://doi.org/10.3389/FPUBH.2021.624559
- Dror, A. A., Morozov, N., Daoud, A., Namir, Y., Yakir, O., Shachar, Y., Lifshitz, M., Segal, E., Fisher, L., Mizrachi, M., Eisenbach, N., Rayan, D., Gruber, M., Bashkin, A., Kaykov, E., Barhoum, M., Edelstein, M., & Sela, E. (2022). Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PloS One, 17(2), e0263069. https://doi.org/10.1371/JOURNAL.PONE.0263069
- Armitage, R. C. (2021). COVID-19 and time spent outdoors: a golden opportunity for health promotion. Public Health, 198, e4. https://doi.org/10.1016/J.PUHE.2021.03.018
- Gazit, S., Shlezinger, R., Perez, G., Lotan, R., Peretz, A., Ben-Tov, A., Cohen, D., Muhsen, K., Chodick, G., & Patalon, T. (2021). Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections. MedRxiv, 2021.08.24.21262415. https://doi.org/10.1101/2021.08.24.21262415
- Wang, S. Y., Juthani, P. V., Borges, K. A., Shallow, M. K., Gupta, A., Price, C., Won, C. H., & Chun, H. J. (2022). Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era. The Lancet Microbe, 3(1), e4–e5. https://doi.org/10.1016/S2666-5247(21)00306-2/ATTACHMENT/F3BCC64F-C6DA-4EC2-BFA0-B0AEDC960D07/MMC1.PDF
- Hathaway, D., Pandav, K., Patel, M., Riva-Moscoso, A., Singh, B. M., Patel, A., Min, Z. C., Singh-Makkar, S., Sana, M. K., Sanchez-Dopazo, R., Desir, R., Fahem, M. M. M., Manella, S., Rodriguez, I., Alvarez, A., & Abreu, R. (2020). Omega 3 Fatty Acids and COVID-19: A Comprehensive Review. Infection & Chemotherapy, 52(4), 478. https://doi.org/10.3947/IC.2020.52.4.478
- Asher, A., Tintle, N. L., Myers, M., Lockshon, L., Bacareza, H., & Harris, W. S. (2021). Blood omega-3 fatty acids and death from COVID-19: A pilot study. Prostaglandins, Leukotrienes and Essential Fatty Acids, 166, 102250. https://doi.org/10.1016/J.PLEFA.2021.102250
- Toscano, G. A. da S., de Araújo, I. I., de Souza, T. A., Barbosa Mirabal, I. R., & de Vasconcelos Torres, G. (2021). Vitamin C and D supplementation and the severity of COVID-19: A protocol for systematic review and meta-analysis. Medicine, 100(26), e26427. https://doi.org/10.1097/MD.0000000000026427
- Fakhrolmobasheri, M., Mazaheri-Tehrani, S., Kieliszek, M., Zeinalian, M., Abbasi, M., Karimi, F., & Mozafari, A. M. (2021). COVID-19 and Selenium Deficiency: a Systematic Review. Biological Trace Element Research, 1. https://doi.org/10.1007/S12011-021-02997-4
- Förstermann, U., & Sessa, W. C. (2012). Nitric oxide synthases: regulation and function. European Heart Journal, 33(7). https://doi.org/10.1093/EURHEARTJ/EHR304
- Zhao, Y., Vanhoutte, P. M., & Leung, S. W. S. (2015). Vascular nitric oxide: Beyond eNOS. Journal of Pharmacological Sciences, 129(2), 83–94. https://doi.org/10.1016/J.JPHS.2015.09.002
- Mir, J. M., & Maurya, R. C. (2020). Nitric oxide boosters as defensive agents against COVID-19 infection: an opinion. Journal of Biomolecular Structure & Dynamics, 1. https://doi.org/10.1080/07391102.2020.1852969
- Adebayo, A., Varzideh, F., Wilson, S., Gambardella, J., Eacobacci, M., Jankauskas, S. S., Donkor, K., Kansakar, U., Trimarco, V., Mone, P., Lombardi, A., & Santulli, G. (2021). l-Arginine and COVID-19: An Update. Nutrients, 13(11). https://doi.org/10.3390/NU13113951
- Anand David, A. V., Arulmoli, R., & Parasuraman, S. (2016). Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacognosy Reviews, 10(20), 84. https://doi.org/10.4103/0973-7847.194044
- Saeedi-Boroujeni, A., & Mahmoudian-Sani, M. R. (2021). Anti-inflammatory potential of Quercetin in COVID-19 treatment. Journal of Inflammation (United Kingdom), 18(1), 1–9. https://doi.org/10.1186/S12950-021-00268-6/FIGURES/1
- Derosa, G., Maffioli, P., D’Angelo, A., & Di Pierro, F. (2021). A role for quercetin in coronavirus disease 2019 (COVID-19). Phytotherapy Research, 35(3), 1230–1236. https://doi.org/10.1002/PTR.6887
- Manjunath, S. H., & Thimmulappa, R. K. (2021). Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19. Journal of Pharmaceutical Analysis. https://doi.org/10.1016/J.JPHA.2021.09.009
- Agrawal, P. K., Agrawal, C., & Blunden, G. (2020). Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations: Https://Doi.Org/10.1177/1934578X20976293, 15(12), 1–10. https://doi.org/10.1177/1934578X20976293
- Di Pierro, F., Iqtadar, S., Khan, A., Ullah Mumtaz, S., Masud Chaudhry, M., Bertuccioli, A., Derosa, G., Maffioli, P., Togni, S., Riva, A., Allegrini, P., & Khan, S. (2021). Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial. International Journal of General Medicine, 14, 2807. https://doi.org/10.2147/IJGM.S318949
- Pal, A., Squitti, R., Picozza, M., Pawar, A., Rongioletti, M., Dutta, A. K., Sahoo, S., Goswami, K., Sharma, P., & Prasad, R. (2021). Zinc and COVID-19: Basis of Current Clinical Trials. Biological Trace Element Research, 199(8), 2882. https://doi.org/10.1007/S12011-020-02437-9
- Gordon, A. M., & Hardigan, P. C. (2021). A Case-Control Study for the Effectiveness of Oral Zinc in the Prevention and Mitigation of COVID-19. Frontiers in Medicine, 8, 2474. https://doi.org/10.3389/FMED.2021.756707/BIBTEX
- Cross, K. M., Landis, D. M., Sehgal, L., & Payne, J. D. (2021). Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy. Endocrine Practice, 27(8), 850. https://doi.org/10.1016/J.EPRAC.2021.06.001
- Dinicolantonio, J. J., McCarty, M., & Barroso-Aranda, J. (2021). Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections. Open Heart, 8(1), e001568. https://doi.org/10.1136/OPENHRT-2020-001568
- Khazdair, M. R., Ghafari, S., & Sadeghi, M. (2021). Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19. Pharmaceutical Biology, 59(1), 696. https://doi.org/10.1080/13880209.2021.1931353
- Koshak, A. E., Koshak, E. A., Mobeireek, A. F., Badawi, M. A., Wali, S. O., Malibary, H. M., Atwah, A. F., Alhamdan, M. M., Almalki, R. A., & Madani, T. A. (2021). Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complementary Therapies in Medicine, 61, 102769. https://doi.org/10.1016/J.CTIM.2021.102769
- da Silva Santos, P. S., da Fonseca Orcina, B., Machado, R. R. G., Vilhena, F. V., da Costa Alves, L. M., Zangrando, M. S. R., de Oliveira, R. C., Soares, M. Q. S., Simão, A. N. C., Pietro, E. C. I. N., Kuroda, J. P. G., de Almeida Benjamim, I. A., Araujo, D. B., Toma, S. H., Flor, L., Araki, K., & Durigon, E. L. (2021). Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trial. Scientific Reports 2021 11:1, 11(1), 1–10. https://doi.org/10.1038/s41598-021-99013-5
- Carrouel, F., Valette, M., Gadea, E., Esparcieux, A., Illes, G., Langlois, M. E., Perrier, H., Dussart, C., Tramini, P., Ribaud, M., Bouscambert-Duchamp, M., & Bourgeois, D. (2021). Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial. Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(10), 1494–1501. https://doi.org/10.1016/J.CMI.2021.05.028
- Xu, C., Wang, A., Hoskin, E. R., Cugini, C., Fine, D. H., Markowitz, K., & Chang, T. L. (2021). Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity In Vitro. Pathogens 2021, Vol. 10, Page 272, 10(3), 272. https://doi.org/10.3390/PATHOGENS10030272